tetano
Editor, Senior Moderator
J Med Virol. 2011 Apr 22. doi: 10.1002/jmv.22078. [Epub ahead of print]
Antigenic and genetic variation in the hemagglutinins of H1N1 and H3N2 human influenza a viruses in the Shanghai area from 2005 to 2008.
Ren XW, Ju LW, Yang JX, Lv XH, Jiang LF, Zhao NQ, Jiang QW.
Source
Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
Abstract
Continued rapid evolution of the influenza A virus is responsible for annual epidemics and occasional pandemics in the Shanghai area. In the present study, the representative strains of A/H1N1 and A/H3N2 influenza viruses isolated in the Shanghai area from 2005 to 2008 were antigenically and genetically characterized. The antigenic cartography method was carried out to visualize the hemagglutination-inhibition data. Antigenic differences were detected between circulating A/H1N1 strains isolated from 2005 to 2006 and the epidemic A/H1N1 strains isolated in 2008, which were found to be associated with the amino acid substitution K140E in HA1. The present vaccine strain A/Brisbane/59/2007 is considered to be capable of providing sufficient immunity against most of the circulating A/H1N1 viruses isolated in 2008 from the Shanghai population. The study showed that there were significant antigenic differences between the epidemic A/H3N2 strains isolated in 2007 and 2008, suggesting that antigenic drift had occurred in the A/H3N2 strains isolated in 2008. The P194L mutation was thought to be responsible for the antigenic evolution of influenza A/H3N2 viruses isolated from Shanghai in 2008. Evidence of antigenic drift suggests that the influenza A/H3N2 vaccine component needs to be updated. J. Med. Virol. ? 2011 Wiley-Liss, Inc.
Copyright ? 2011 Wiley-Liss, Inc.
PMID:
21520138
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21520138
Antigenic and genetic variation in the hemagglutinins of H1N1 and H3N2 human influenza a viruses in the Shanghai area from 2005 to 2008.
Ren XW, Ju LW, Yang JX, Lv XH, Jiang LF, Zhao NQ, Jiang QW.
Source
Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
Abstract
Continued rapid evolution of the influenza A virus is responsible for annual epidemics and occasional pandemics in the Shanghai area. In the present study, the representative strains of A/H1N1 and A/H3N2 influenza viruses isolated in the Shanghai area from 2005 to 2008 were antigenically and genetically characterized. The antigenic cartography method was carried out to visualize the hemagglutination-inhibition data. Antigenic differences were detected between circulating A/H1N1 strains isolated from 2005 to 2006 and the epidemic A/H1N1 strains isolated in 2008, which were found to be associated with the amino acid substitution K140E in HA1. The present vaccine strain A/Brisbane/59/2007 is considered to be capable of providing sufficient immunity against most of the circulating A/H1N1 viruses isolated in 2008 from the Shanghai population. The study showed that there were significant antigenic differences between the epidemic A/H3N2 strains isolated in 2007 and 2008, suggesting that antigenic drift had occurred in the A/H3N2 strains isolated in 2008. The P194L mutation was thought to be responsible for the antigenic evolution of influenza A/H3N2 viruses isolated from Shanghai in 2008. Evidence of antigenic drift suggests that the influenza A/H3N2 vaccine component needs to be updated. J. Med. Virol. ? 2011 Wiley-Liss, Inc.
Copyright ? 2011 Wiley-Liss, Inc.
PMID:
21520138
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21520138