tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2014 Feb 19. [Epub ahead of print]
Antigenic and genetic evolution of Low Pathogenic Avian influenza viruses (H7N3) following heterologous vaccination.
Beato MS1, Xu Y, Long LP, Capua I, Wan XF.
Author information
Abstract
Outbreaks of low pathogenic avian influenza (LPAI) viruses of the H7N3 subtype were first detected in Italy in October 2002, the virus continued to circulate between 2002 and 2004 in a densely populated poultry area in the Northeast. This virus circulated in unvaccinated and vaccinated poultry farms and the infection was controlled in August 2003 by culling, control of movements, improved bio-security and heterologous vaccination. In 2004, H7N3 re-occurred in vaccinated poultry farms in which infection was successfully controlled by the vaccination program. To shed light on the occurrence, temporal pattern and genetic basis of antigenic drift for Avian Influenza viruses (AIVs) in absence and presence of heterologous vaccination, a collection of H7N3 viruses isolated from 2002 and 2004 were characterised genetically and antigenically. Molecular analysis showed that viruses isolated in the 2004 outbreaks after the implementation of vaccination acquired specific amino acid signatures, most of which were located at reported antibody binding sites of the haemagglutinin (HA) protein. Antigenic characterization of these 2004 isolates showed that they were antigenically different when compared to those isolated prior to the implementation of vaccination. This is the first report on antigenic and genetic evolution of H7 LPAI viruses following the application of heterologous vaccination in poultry. These findings may have impact on control strategies to combat AI infections in poultry based on vaccination.
PMID:
24554694
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24554694
Antigenic and genetic evolution of Low Pathogenic Avian influenza viruses (H7N3) following heterologous vaccination.
Beato MS1, Xu Y, Long LP, Capua I, Wan XF.
Author information
Abstract
Outbreaks of low pathogenic avian influenza (LPAI) viruses of the H7N3 subtype were first detected in Italy in October 2002, the virus continued to circulate between 2002 and 2004 in a densely populated poultry area in the Northeast. This virus circulated in unvaccinated and vaccinated poultry farms and the infection was controlled in August 2003 by culling, control of movements, improved bio-security and heterologous vaccination. In 2004, H7N3 re-occurred in vaccinated poultry farms in which infection was successfully controlled by the vaccination program. To shed light on the occurrence, temporal pattern and genetic basis of antigenic drift for Avian Influenza viruses (AIVs) in absence and presence of heterologous vaccination, a collection of H7N3 viruses isolated from 2002 and 2004 were characterised genetically and antigenically. Molecular analysis showed that viruses isolated in the 2004 outbreaks after the implementation of vaccination acquired specific amino acid signatures, most of which were located at reported antibody binding sites of the haemagglutinin (HA) protein. Antigenic characterization of these 2004 isolates showed that they were antigenically different when compared to those isolated prior to the implementation of vaccination. This is the first report on antigenic and genetic evolution of H7 LPAI viruses following the application of heterologous vaccination in poultry. These findings may have impact on control strategies to combat AI infections in poultry based on vaccination.
PMID:
24554694
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24554694