tetano
Editor, Senior Moderator
Curr Opin Virol. 2017 Jan 11;22:89-96. doi: 10.1016/j.coviro.2016.12.002. [Epub ahead of print]
[h=1]Antibody-dependent cellular cytotoxicity and influenza virus.[/h] Vanderven HA[SUP]1[/SUP], Jegaskanda S[SUP]1[/SUP], Wheatley AK[SUP]1[/SUP], Kent SJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Antibodies are a key defence against influenza infection and disease, but neutralizing antibodies are often strain-specific and of limited utility against divergent or pandemic viruses. There is now considerable evidence that influenza-specific antibodies with Fc-mediated effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can assist in the clearance of influenza infection in vitro and in animal models. Further, ADCC-mediating antibodies that recognize a broad array of influenza strains are common in humans, likely as a result of being regularly exposed to influenza infections. The concept that influenza-specific ADCC can assist in the partial control of influenza infections in humans is gaining momentum. This review examines the utility of influenza-specific ADCC antibodies.
Copyright ? 2016 Elsevier B.V. All rights reserved.
PMID: 28088123 DOI: 10.1016/j.coviro.2016.12.002
[PubMed - as supplied by publisher]
[h=1]Antibody-dependent cellular cytotoxicity and influenza virus.[/h] Vanderven HA[SUP]1[/SUP], Jegaskanda S[SUP]1[/SUP], Wheatley AK[SUP]1[/SUP], Kent SJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Antibodies are a key defence against influenza infection and disease, but neutralizing antibodies are often strain-specific and of limited utility against divergent or pandemic viruses. There is now considerable evidence that influenza-specific antibodies with Fc-mediated effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can assist in the clearance of influenza infection in vitro and in animal models. Further, ADCC-mediating antibodies that recognize a broad array of influenza strains are common in humans, likely as a result of being regularly exposed to influenza infections. The concept that influenza-specific ADCC can assist in the partial control of influenza infections in humans is gaining momentum. This review examines the utility of influenza-specific ADCC antibodies.
Copyright ? 2016 Elsevier B.V. All rights reserved.
PMID: 28088123 DOI: 10.1016/j.coviro.2016.12.002
[PubMed - as supplied by publisher]