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From Medscape Pediatrics > Viewpoints
Antibiotic History and MRSA in Children
William T. Basco, Jr., MD, MS
Authors and Disclosures
Posted: 02/21/2012
Antibacterial Drugs and the Risk of Community-Associated Methicillin-Resistant Staphylococcus aureus in Children
Schneider-Lindner V, Quach C, Hanley JA, Suissa S
Arch Pediatr Adolesc Med. 2011;165:1107-1114
Study Summary
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasing problem. Although most CA-MRSA infections involve the skin and soft tissue, CA-MRSA can also cause devastating invasive disease. Other investigators have examined different risk factors for children acquiring a CA-MRSA infection, but none have previously explored the relationship between antibiotic exposure and risk of developing infection with CA-MRSA. This study used existing data from the General Practice Research Database of the United Kingdom, which includes prescription data from over 400 general practices. Participants were 0-19 years of age and had been seen between 1993 and 2007. The investigators first identified cases of CA-MRSA using administrative diagnostic codes, and then reconstructed the children's medical histories to evaluate previous medical diagnoses and prescriptions. Cases were matched with controls using month and year of birth.
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http://www.medscape.com/viewarticle/758609?src=mp&spon=9
Antibiotic History and MRSA in Children
William T. Basco, Jr., MD, MS
Authors and Disclosures
Posted: 02/21/2012
Antibacterial Drugs and the Risk of Community-Associated Methicillin-Resistant Staphylococcus aureus in Children
Schneider-Lindner V, Quach C, Hanley JA, Suissa S
Arch Pediatr Adolesc Med. 2011;165:1107-1114
Study Summary
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasing problem. Although most CA-MRSA infections involve the skin and soft tissue, CA-MRSA can also cause devastating invasive disease. Other investigators have examined different risk factors for children acquiring a CA-MRSA infection, but none have previously explored the relationship between antibiotic exposure and risk of developing infection with CA-MRSA. This study used existing data from the General Practice Research Database of the United Kingdom, which includes prescription data from over 400 general practices. Participants were 0-19 years of age and had been seen between 1993 and 2007. The investigators first identified cases of CA-MRSA using administrative diagnostic codes, and then reconstructed the children's medical histories to evaluate previous medical diagnoses and prescriptions. Cases were matched with controls using month and year of birth.
..
subscription required
http://www.medscape.com/viewarticle/758609?src=mp&spon=9