Tonka
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Re: Tamiflu resistance in A/H1N1 flu - historical compilation of news
Re: Tamiflu resistance in A/H1N1 flu - historical compilation of news
http://www.milenio.com/node/393298
Mutation A/H1N1 virus, resistant to Tamiflu
Tests confirm the change so far has been defined "not serious".
Wed, 03/03/2010 - 05:06
The official says the vaccination is going well. Photo: H?ctor T?llez / Archive Mexico.- The Ministry of Health reported the first mutation detected in the influenza A/H1N1 virus in the position of H274Y in neuraminidase gene (NA) in a patient ten months old, who survived the disease but showed resistance to the antiviral oseltamivir (Tamiflu).
The infant "is good, with mild cough and runny nose alone, according to the report he released his mother by telephone on March 1.
The Institute of Epidemiological Diagnosis and Reference (INDRE) conducted laboratory tests using PCR in real time, and confirmed the mutation, so far has been defined not serious.
"This finding does not change the treatment policy in the future, since it is the only strain found resistant of 420 sequenced, which means less resistance to .25%."
The SSA has not reported whether this case could trigger a wave of people infected oseltamivir resistance, and so must use the accumulated reserve in case of zanamivir resistance.
Little is originally from Ecatepec, Mexico state, was admitted on January 4 Pediatric Hospital La Villa, for mild respiratory distress syndrome, malnutrition grade one and bronchiolitis. She was discharged after showing satisfactory progress smoothly.
Joined ten days later to Children's Hospital of Mexico "Federico Gomez", diagnosed with severe pneumonia, moderate malnutrition and influenza-like illness.
After control was achieved, was taken to Children's Hospital in the town to continue treatment, where he was discharged on Feb. 3.
The federal government recognized a serious case of H1N1 mutation, as in Norway and, therefore, began to shape a "small strategic reserve" of over 100 thousand zanamivir treatment in case of detection of patients resistant to Tamiflu .
"If there was a mutation that causes a resistance to Tamiflu, an antiviral drug would be changed for another. Mexico is ready with an alternate booking more than 100 thousand zanamivir treatment is still small, but we would cope. At this point we are not facing that situation, "noted Alejandro Macias, national commissioner for the care of influenza.
In turn, the Director National Institute of Epidemiological Diagnosis and Reference, Celia Alpuche, said the Mexican case of severe mutation corresponds to the second patient treated at INER in April when the pandemic began.
A few months ago, WHO issued an alert and suggested to Norway, Brazil, China, Japan, Ukraine, USA and Mexico, where mutations have been reported, carrying out more detailed summaries and sequencing, in order to determine whether or not more virulent .
Dismissing raise alert
? ? ? The Federal Ministry of Health ruled that in March, as forecast, raise the alert for the H1N1 pandemic contingency because it continues to increase, more mild aunquede, the number of infections: 71 thousand 90 cases, and 88 thousand deaths (nine more than the previous report).
Jose Angel Cordova, Secretary of Health, explained that almost a year after the outbreak of the pandemic by the new virus called H1N1, high transmissibility, but with minor consequences and not so serious for most, the Audit Committee Epidemiological evaluated even if it is time to lift the health contingency.
Meanwhile, the municipal government will continue with the alert to respond to outbreaks of H1N1, so you will expand the vaccination campaign Metrobus stations and some trolleybus, in order to reach more segments of the population. (Mexico ? Blanca Valadez and Miriam Castillo)
Blanca Valadez
Re: Tamiflu resistance in A/H1N1 flu - historical compilation of news
http://www.milenio.com/node/393298
Mutation A/H1N1 virus, resistant to Tamiflu
Tests confirm the change so far has been defined "not serious".
Wed, 03/03/2010 - 05:06
The official says the vaccination is going well. Photo: H?ctor T?llez / Archive Mexico.- The Ministry of Health reported the first mutation detected in the influenza A/H1N1 virus in the position of H274Y in neuraminidase gene (NA) in a patient ten months old, who survived the disease but showed resistance to the antiviral oseltamivir (Tamiflu).
The infant "is good, with mild cough and runny nose alone, according to the report he released his mother by telephone on March 1.
The Institute of Epidemiological Diagnosis and Reference (INDRE) conducted laboratory tests using PCR in real time, and confirmed the mutation, so far has been defined not serious.
"This finding does not change the treatment policy in the future, since it is the only strain found resistant of 420 sequenced, which means less resistance to .25%."
The SSA has not reported whether this case could trigger a wave of people infected oseltamivir resistance, and so must use the accumulated reserve in case of zanamivir resistance.
Little is originally from Ecatepec, Mexico state, was admitted on January 4 Pediatric Hospital La Villa, for mild respiratory distress syndrome, malnutrition grade one and bronchiolitis. She was discharged after showing satisfactory progress smoothly.
Joined ten days later to Children's Hospital of Mexico "Federico Gomez", diagnosed with severe pneumonia, moderate malnutrition and influenza-like illness.
After control was achieved, was taken to Children's Hospital in the town to continue treatment, where he was discharged on Feb. 3.
The federal government recognized a serious case of H1N1 mutation, as in Norway and, therefore, began to shape a "small strategic reserve" of over 100 thousand zanamivir treatment in case of detection of patients resistant to Tamiflu .
"If there was a mutation that causes a resistance to Tamiflu, an antiviral drug would be changed for another. Mexico is ready with an alternate booking more than 100 thousand zanamivir treatment is still small, but we would cope. At this point we are not facing that situation, "noted Alejandro Macias, national commissioner for the care of influenza.
In turn, the Director National Institute of Epidemiological Diagnosis and Reference, Celia Alpuche, said the Mexican case of severe mutation corresponds to the second patient treated at INER in April when the pandemic began.
A few months ago, WHO issued an alert and suggested to Norway, Brazil, China, Japan, Ukraine, USA and Mexico, where mutations have been reported, carrying out more detailed summaries and sequencing, in order to determine whether or not more virulent .
Dismissing raise alert
? ? ? The Federal Ministry of Health ruled that in March, as forecast, raise the alert for the H1N1 pandemic contingency because it continues to increase, more mild aunquede, the number of infections: 71 thousand 90 cases, and 88 thousand deaths (nine more than the previous report).
Jose Angel Cordova, Secretary of Health, explained that almost a year after the outbreak of the pandemic by the new virus called H1N1, high transmissibility, but with minor consequences and not so serious for most, the Audit Committee Epidemiological evaluated even if it is time to lift the health contingency.
Meanwhile, the municipal government will continue with the alert to respond to outbreaks of H1N1, so you will expand the vaccination campaign Metrobus stations and some trolleybus, in order to reach more segments of the population. (Mexico ? Blanca Valadez and Miriam Castillo)
Blanca Valadez
