tetano
Editor, Senior Moderator
Nat Prod Res. 2012 Nov 19. [Epub ahead of print]
Anti-H5N1 virus new diglyceride ester from the Red Sea grass Thallasodendron ciliatum.
Ibrahim AK, Youssef AI, Arafa AS, Foad R, Radwan MM, Ross S, Hassanean HA, Ahmed SA.
Source
a Department of Pharmacognosy , Faculty of Pharmacy, Suez Canal University , 41522 , Ismailia , Egypt.
Abstract
Some Egyptian plants were screened against highly pathogenic avian influenza strain H5N1 using plaque inhibition assay in Madin-Darby canine kidney. The results indicated that the extracts of Red Sea grass Thallasodendron ciliatum possessed potent antiviral activity (100% inhibition at the concentration of 1 μg mL(- 1)). The bioactivity-guided fractionations led to the isolation of a new diglyceride ester (1) along with asebotin (2) for the first time from the plant. The two isolates showed reduction of virus titre by 67.26% and 53.81% inhibition at concentration of 1 ng mL(- 1), respectively.
PMID:
23163517
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23163517
Anti-H5N1 virus new diglyceride ester from the Red Sea grass Thallasodendron ciliatum.
Ibrahim AK, Youssef AI, Arafa AS, Foad R, Radwan MM, Ross S, Hassanean HA, Ahmed SA.
Source
a Department of Pharmacognosy , Faculty of Pharmacy, Suez Canal University , 41522 , Ismailia , Egypt.
Abstract
Some Egyptian plants were screened against highly pathogenic avian influenza strain H5N1 using plaque inhibition assay in Madin-Darby canine kidney. The results indicated that the extracts of Red Sea grass Thallasodendron ciliatum possessed potent antiviral activity (100% inhibition at the concentration of 1 μg mL(- 1)). The bioactivity-guided fractionations led to the isolation of a new diglyceride ester (1) along with asebotin (2) for the first time from the plant. The two isolates showed reduction of virus titre by 67.26% and 53.81% inhibition at concentration of 1 ng mL(- 1), respectively.
PMID:
23163517
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23163517