tetano
Editor, Senior Moderator
Vaccine. 2012 Feb 15. [Epub ahead of print]
Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus.
Lei T, Siu KL, Kok KH, Chan KH, Chan EY, Hung IF, To KK, Li PC, Zhou J, Zheng BJ, Yuen KY, Wang M, Jin DY.
Source
Department of Pathology, School of Medicine, Xi'an Jiaotong University, Xi'an, China; Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Abstract
Recipients of influenza A (H1N1) vaccine in 1976 had an increased risk for the neurologic disorder Guillain-Barr? syndrome (GBS). Anti-ganglioside antibodies, which might be associated with the development of GBS, were previously reported to be induced in mice immunized with an H1N1 vaccine of 1976 or another influenza vaccine. In this study we analyzed anti-ganglioside antibodies in human subjects infected with or vaccinated against 2009 pandemic H1N1, including eight patients diagnosed to have post-vaccination GBS. Antibodies against GM1 or another ganglioside were not detected in any subject or in vaccinated mice. Our results did not support the induction of anti-ganglioside antibodies by influenza viruses or vaccines.
Copyright © 2012. Published by Elsevier Ltd.
PMID:
22342549
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22342549
Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus.
Lei T, Siu KL, Kok KH, Chan KH, Chan EY, Hung IF, To KK, Li PC, Zhou J, Zheng BJ, Yuen KY, Wang M, Jin DY.
Source
Department of Pathology, School of Medicine, Xi'an Jiaotong University, Xi'an, China; Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Abstract
Recipients of influenza A (H1N1) vaccine in 1976 had an increased risk for the neurologic disorder Guillain-Barr? syndrome (GBS). Anti-ganglioside antibodies, which might be associated with the development of GBS, were previously reported to be induced in mice immunized with an H1N1 vaccine of 1976 or another influenza vaccine. In this study we analyzed anti-ganglioside antibodies in human subjects infected with or vaccinated against 2009 pandemic H1N1, including eight patients diagnosed to have post-vaccination GBS. Antibodies against GM1 or another ganglioside were not detected in any subject or in vaccinated mice. Our results did not support the induction of anti-ganglioside antibodies by influenza viruses or vaccines.
Copyright © 2012. Published by Elsevier Ltd.
PMID:
22342549
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22342549