tetano
Editor, Senior Moderator
Vaccine. 2015 Nov 21. pii: S0264-410X(15)01585-6. doi: 10.1016/j.vaccine.2015.10.129. [Epub ahead of print]
[h=1]Annual influenza vaccination reduces total hospitalization in patients with chronic hepatitis B virus infection: A population-based analysis.[/h] Su FH[SUP]1[/SUP], Huang YL[SUP]2[/SUP], Sung FC[SUP]3[/SUP], Su CT[SUP]4[/SUP], Hsu WH[SUP]5[/SUP], Chang SN[SUP]3[/SUP], Yeh CC[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] This study evaluated hospitalization and mortality in patients with chronic hepatitis B virus infection (HBV (+)) and matched comparison patients after stratifying the patients according to annual influenza vaccination (Vaccine (+)).
[h=4]METHODS:[/h] Data from Taiwan's National Health Insurance program from 2000 to 2009 were used to identify HBV(+)/vaccine(+) (n=4434), HBV(+)/Vaccine(-) (n=3646), HBV(-)/Vaccine(+) (n=8868), and HBV(-)/Vaccine(-) (n=8868) cohorts. The risk of pneumonia/influenza, respiratory failure, intensive care, hospitalization, and mortality in the four cohorts was evaluated.
[h=4]RESULTS:[/h] The total hospitalization rate was significantly lower in patients with chronic HBV infection who received an annual influenza vaccination than in chronic HBV-infected patients who did not receive an influenza vaccination (16.29 vs. 24.02 per 100 person-years), contributing to an adjusted hazard ratio (HR) of 0.56 (95% confidence interval (CI)=0.50-0.62). The HBV(+)/Vaccine(+) cohort also had lower risks than the HBV(+)/Vaccine(-) cohort for pneumonia and influenza (adjusted HR=0.79, 95% CI=0.67-0.92), intensive care unit admission (adjusted HR=0.33, 95% CI=0.25-0.43), and mortality (adjusted HR=0.19, 95% CI=0.15-0.24).
[h=4]CONCLUSIONS:[/h] Our results suggest that annual influenza vaccination can reduce the risk of hospitalization and mortality in patients with chronic HBV infection.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Hepatitis B virus; Influenza; Population-based study; Vaccination
PMID: 26614589 [PubMed - as supplied by publisher]
[h=1]Annual influenza vaccination reduces total hospitalization in patients with chronic hepatitis B virus infection: A population-based analysis.[/h] Su FH[SUP]1[/SUP], Huang YL[SUP]2[/SUP], Sung FC[SUP]3[/SUP], Su CT[SUP]4[/SUP], Hsu WH[SUP]5[/SUP], Chang SN[SUP]3[/SUP], Yeh CC[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] This study evaluated hospitalization and mortality in patients with chronic hepatitis B virus infection (HBV (+)) and matched comparison patients after stratifying the patients according to annual influenza vaccination (Vaccine (+)).
[h=4]METHODS:[/h] Data from Taiwan's National Health Insurance program from 2000 to 2009 were used to identify HBV(+)/vaccine(+) (n=4434), HBV(+)/Vaccine(-) (n=3646), HBV(-)/Vaccine(+) (n=8868), and HBV(-)/Vaccine(-) (n=8868) cohorts. The risk of pneumonia/influenza, respiratory failure, intensive care, hospitalization, and mortality in the four cohorts was evaluated.
[h=4]RESULTS:[/h] The total hospitalization rate was significantly lower in patients with chronic HBV infection who received an annual influenza vaccination than in chronic HBV-infected patients who did not receive an influenza vaccination (16.29 vs. 24.02 per 100 person-years), contributing to an adjusted hazard ratio (HR) of 0.56 (95% confidence interval (CI)=0.50-0.62). The HBV(+)/Vaccine(+) cohort also had lower risks than the HBV(+)/Vaccine(-) cohort for pneumonia and influenza (adjusted HR=0.79, 95% CI=0.67-0.92), intensive care unit admission (adjusted HR=0.33, 95% CI=0.25-0.43), and mortality (adjusted HR=0.19, 95% CI=0.15-0.24).
[h=4]CONCLUSIONS:[/h] Our results suggest that annual influenza vaccination can reduce the risk of hospitalization and mortality in patients with chronic HBV infection.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Hepatitis B virus; Influenza; Population-based study; Vaccination
PMID: 26614589 [PubMed - as supplied by publisher]