tetano
Editor, Senior Moderator
Ann Vasc Surg
. 2020 Aug 10;S0890-5096(20)30642-7.
doi: 10.1016/j.avsg.2020.08.004. Online ahead of print.
Acute lower limb ischemia as clinical presentation of COVID-19 infection
Cristina Mietto[SUP] 1 [/SUP], Valentina Salice[SUP] 2 [/SUP], Matteo Ferraris[SUP] 3 [/SUP], Gianmarco Zuccon[SUP] 3 [/SUP], Federico Valdambrini[SUP] 2 [/SUP], Giorgio Piazzalunga[SUP] 3 [/SUP], Anna Maria Socrate[SUP] 3 [/SUP], Danilo Radrizzani[SUP] 2 [/SUP]
Affiliations
Abstract
Novel 2019 coronavirus (COVID-19) infection usually causes a respiratory disease, that may vary in severity from mild symptoms to severe pneumonia with multiple organ failure. Coagulation abnormalities are frequent, and reports suggest that COVID-19 may predispose to venous and arterial thrombotic complications. We report a case of acute lower limb ischemia and resistance to heparin as the onset of COVID-19 disease, preceding the development of respiratory failure. This case highlights that the shift of coagulation profile towards hypercoagulability was associated with the acute ischemic event and influenced the therapy.
Keywords: COVID-19; SARS-CoV2; acute limb ischemia (ALI); arterial thrombosis; hypercoagulable states.
. 2020 Aug 10;S0890-5096(20)30642-7.
doi: 10.1016/j.avsg.2020.08.004. Online ahead of print.
Acute lower limb ischemia as clinical presentation of COVID-19 infection
Cristina Mietto[SUP] 1 [/SUP], Valentina Salice[SUP] 2 [/SUP], Matteo Ferraris[SUP] 3 [/SUP], Gianmarco Zuccon[SUP] 3 [/SUP], Federico Valdambrini[SUP] 2 [/SUP], Giorgio Piazzalunga[SUP] 3 [/SUP], Anna Maria Socrate[SUP] 3 [/SUP], Danilo Radrizzani[SUP] 2 [/SUP]
Affiliations
- PMID: 32791191
- DOI: 10.1016/j.avsg.2020.08.004
Abstract
Novel 2019 coronavirus (COVID-19) infection usually causes a respiratory disease, that may vary in severity from mild symptoms to severe pneumonia with multiple organ failure. Coagulation abnormalities are frequent, and reports suggest that COVID-19 may predispose to venous and arterial thrombotic complications. We report a case of acute lower limb ischemia and resistance to heparin as the onset of COVID-19 disease, preceding the development of respiratory failure. This case highlights that the shift of coagulation profile towards hypercoagulability was associated with the acute ischemic event and influenced the therapy.
Keywords: COVID-19; SARS-CoV2; acute limb ischemia (ALI); arterial thrombosis; hypercoagulable states.