tetano
Editor, Senior Moderator
Ann Transl Med
. 2021 Jan;9(1):10.
doi: 10.21037/atm-20-4850.
Effect of liver injury on prognosis and treatment of hospitalized patients with COVID-19 pneumonia
Guo-Guang Ma[SUP] 1 [/SUP], Ya-Xing Shen[SUP] 2 [/SUP], Ling Wu[SUP] 3 [/SUP], Zhe Luo[SUP] 1 4 [/SUP], Chou-Wen Zhu[SUP] 3 5 [/SUP], Shi-Yao Chen[SUP] 3 5 6 [/SUP], Kai-Huan Yu[SUP] 7 [/SUP], Feng Li[SUP] 3 6 [/SUP]
Affiliations
Abstract
Background: Liver injury is common in patients with coronavirus disease 2019 (COVID-19), although its effect on patient outcomes has not been well studied. This study aimed to evaluate the effect of liver injury on the prognosis and treatment of patients with COVID-19 pneumonia.
Methods: In this retrospective, single-center study, data on 109 hospitalized patients with COVID-19 pneumonia were extracted and analyzed. The primary composite end-point event was the use of mechanical ventilation or death.
Results: At admission, of the 109 patients enrolled, 56 patients (51.4%) were diagnosed with severe disease, and 39 (35.8%) presented with liver injury, which mainly manifested as elevated levels of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) accompanied simultaneously by an increase in the level of γ-glutamyl transferase. A primary composite end-point event occurred in 21 patients (19.3%). Liver injury was more prevalent in patients with severe disease than in those with non-severe disease (46.4% vs. 24.5%, P=0.017). However, there was no significant difference found between severe and non-severe patients in the use of mechanical ventilation, mortality, hospital stay, or use and dosage of glucocorticoids between individuals with and without liver injury (all P>0.05). The degree of disease severity (OR =7.833, 95% CI, 1.834-31.212, P=0.005) and presence of any coexisting illness (OR =4.736, 95% CI, 1.305-17.186, P=0.018) were predictable risk factors for primary composite end-point events, whereas liver injury had no significance in this aspect (OR =0.549, 95% CI, 0.477-5.156, P=0.459).
Conclusions: Liver injury was more common in severe cases of COVID-19 pneumonia than in non-severe cases. However, liver injury had no negative effect on the prognosis and treatment of COVID-19 pneumonia.
Keywords: Coronavirus disease 2019 (COVID-19); clinical prognosis; liver injury; pneumonia; treatment.
. 2021 Jan;9(1):10.
doi: 10.21037/atm-20-4850.
Effect of liver injury on prognosis and treatment of hospitalized patients with COVID-19 pneumonia
Guo-Guang Ma[SUP] 1 [/SUP], Ya-Xing Shen[SUP] 2 [/SUP], Ling Wu[SUP] 3 [/SUP], Zhe Luo[SUP] 1 4 [/SUP], Chou-Wen Zhu[SUP] 3 5 [/SUP], Shi-Yao Chen[SUP] 3 5 6 [/SUP], Kai-Huan Yu[SUP] 7 [/SUP], Feng Li[SUP] 3 6 [/SUP]
Affiliations
- PMID: 33553303
- PMCID: PMC7859738
- DOI: 10.21037/atm-20-4850
Abstract
Background: Liver injury is common in patients with coronavirus disease 2019 (COVID-19), although its effect on patient outcomes has not been well studied. This study aimed to evaluate the effect of liver injury on the prognosis and treatment of patients with COVID-19 pneumonia.
Methods: In this retrospective, single-center study, data on 109 hospitalized patients with COVID-19 pneumonia were extracted and analyzed. The primary composite end-point event was the use of mechanical ventilation or death.
Results: At admission, of the 109 patients enrolled, 56 patients (51.4%) were diagnosed with severe disease, and 39 (35.8%) presented with liver injury, which mainly manifested as elevated levels of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) accompanied simultaneously by an increase in the level of γ-glutamyl transferase. A primary composite end-point event occurred in 21 patients (19.3%). Liver injury was more prevalent in patients with severe disease than in those with non-severe disease (46.4% vs. 24.5%, P=0.017). However, there was no significant difference found between severe and non-severe patients in the use of mechanical ventilation, mortality, hospital stay, or use and dosage of glucocorticoids between individuals with and without liver injury (all P>0.05). The degree of disease severity (OR =7.833, 95% CI, 1.834-31.212, P=0.005) and presence of any coexisting illness (OR =4.736, 95% CI, 1.305-17.186, P=0.018) were predictable risk factors for primary composite end-point events, whereas liver injury had no significance in this aspect (OR =0.549, 95% CI, 0.477-5.156, P=0.459).
Conclusions: Liver injury was more common in severe cases of COVID-19 pneumonia than in non-severe cases. However, liver injury had no negative effect on the prognosis and treatment of COVID-19 pneumonia.
Keywords: Coronavirus disease 2019 (COVID-19); clinical prognosis; liver injury; pneumonia; treatment.