tetano
Editor, Senior Moderator
Ann Transl Med
. 2021 Sep;9(18):1446.
doi: 10.21037/atm-21-3912.
Comparison of severe and critical COVID-19 patients imported from Russia with and without influenza A infection in Heilongjiang Province: a retrospective study
Qingqing Dai[SUP] 1 [/SUP], Ming Ye[SUP] 1 [/SUP], Zhiqiang Tang[SUP] 1 [/SUP], Kaijiang Yu[SUP] 2 [/SUP], Yang Gao[SUP] 2 [/SUP], Zhenyu Yang[SUP] 1 [/SUP], Junbo Zheng[SUP] 1 [/SUP], Shu Zuo[SUP] 1 [/SUP], Yan Liu[SUP] 3 [/SUP], Fengjie Xie[SUP] 4 [/SUP], Qiuyuan Han[SUP] 1 [/SUP], Hua He[SUP] 5 [/SUP], Hongliang Wang[SUP] 1 [/SUP]
Affiliations
Abstract
Background: The rapid spread of coronavirus disease-19 (COVID-19) poses a global health emergency, and cases entering China from Russia are quite diverse. This study explored and compared the clinical characteristics and outcomes of severe and critically ill COVID-19 patients from Russia with and without influenza A infection, treated in a northern Chinese hospital (Russia imported patients).
Methods: A total of 32 severe and critically ill Russia-imported COVID-19 patients treated in the Heilongjiang Imported Severe and Critical COVID-19 Treatment Center from April 6 to May 11, 2020 were included, including 8 cases (group A) with and 24 cases (group B) without influenza A infection. The clinical characteristics of each group were compared, including prolonged hospital stay, duration of oxygen therapy, time from onset to a negative SARS-CoV-2 qRT-PCR RNA (T[SUB]neg[/SUB]) result, and duration of bacterial infection.
Results: The results showed that blood group, PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB], prothrombin time (PT), prothrombin activity (PTA), computed tomography (CT) score, hospital stay, duration of oxygenation therapy, T[SUB]neg[/SUB], and duration of bacterial infection were statistically different between the two groups (P<0.05). Multivariant regression analysis showed that the Sequential Organ Failure Assessment (SOFA) score, C-reactive protein (CRP), and influenza A infection were factors influencing hospital stay; SOFA score, CRP, and CT score were factors influencing the duration of oxygenation therapy; PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB], platelet count (PLT), and CRP were factors influencing T[SUB]neg[/SUB]; and gender, SOFA score, and influenza A infection were factors influencing the duration of bacterial infection.
Conclusions: Influenza A infection is common in Russia-imported COVID-19 patients, which can prolong the hospital stay and duration of bacterial infection. Routinely screening and treating influenza A should be conducted early in such patients.
Keywords: Coronavirus disease-19 influenza A (COVID-19 influenza A); clinical characteristics; clinical outcome; imported patients.
. 2021 Sep;9(18):1446.
doi: 10.21037/atm-21-3912.
Comparison of severe and critical COVID-19 patients imported from Russia with and without influenza A infection in Heilongjiang Province: a retrospective study
Qingqing Dai[SUP] 1 [/SUP], Ming Ye[SUP] 1 [/SUP], Zhiqiang Tang[SUP] 1 [/SUP], Kaijiang Yu[SUP] 2 [/SUP], Yang Gao[SUP] 2 [/SUP], Zhenyu Yang[SUP] 1 [/SUP], Junbo Zheng[SUP] 1 [/SUP], Shu Zuo[SUP] 1 [/SUP], Yan Liu[SUP] 3 [/SUP], Fengjie Xie[SUP] 4 [/SUP], Qiuyuan Han[SUP] 1 [/SUP], Hua He[SUP] 5 [/SUP], Hongliang Wang[SUP] 1 [/SUP]
Affiliations
- PMID: 34733998
- PMCID: PMC8506785
- DOI: 10.21037/atm-21-3912
Abstract
Background: The rapid spread of coronavirus disease-19 (COVID-19) poses a global health emergency, and cases entering China from Russia are quite diverse. This study explored and compared the clinical characteristics and outcomes of severe and critically ill COVID-19 patients from Russia with and without influenza A infection, treated in a northern Chinese hospital (Russia imported patients).
Methods: A total of 32 severe and critically ill Russia-imported COVID-19 patients treated in the Heilongjiang Imported Severe and Critical COVID-19 Treatment Center from April 6 to May 11, 2020 were included, including 8 cases (group A) with and 24 cases (group B) without influenza A infection. The clinical characteristics of each group were compared, including prolonged hospital stay, duration of oxygen therapy, time from onset to a negative SARS-CoV-2 qRT-PCR RNA (T[SUB]neg[/SUB]) result, and duration of bacterial infection.
Results: The results showed that blood group, PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB], prothrombin time (PT), prothrombin activity (PTA), computed tomography (CT) score, hospital stay, duration of oxygenation therapy, T[SUB]neg[/SUB], and duration of bacterial infection were statistically different between the two groups (P<0.05). Multivariant regression analysis showed that the Sequential Organ Failure Assessment (SOFA) score, C-reactive protein (CRP), and influenza A infection were factors influencing hospital stay; SOFA score, CRP, and CT score were factors influencing the duration of oxygenation therapy; PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB], platelet count (PLT), and CRP were factors influencing T[SUB]neg[/SUB]; and gender, SOFA score, and influenza A infection were factors influencing the duration of bacterial infection.
Conclusions: Influenza A infection is common in Russia-imported COVID-19 patients, which can prolong the hospital stay and duration of bacterial infection. Routinely screening and treating influenza A should be conducted early in such patients.
Keywords: Coronavirus disease-19 influenza A (COVID-19 influenza A); clinical characteristics; clinical outcome; imported patients.