tetano
Editor, Senior Moderator
Ann Neurol
. 2024 Jun 27.
doi: 10.1002/ana.27016. Online ahead of print. Inflammation-Triggered Enlargement of Choroid Plexus in Subacute COVID-19 Patients with Neurological Symptoms
Alexander Rau[SUP] #[/SUP][SUP] 1 [/SUP], Gabriel Gonzalez-Escamilla[SUP] #[/SUP][SUP] 2 [/SUP], Nils Schroeter[SUP] 3 [/SUP], Ahmed Othmann[SUP] 4 [/SUP], Andrea Dressing[SUP] 3 [/SUP], Cornelius Weiller[SUP] 3 [/SUP], Horst Urbach[SUP] 1 [/SUP], Marco Reisert[SUP] 5 6 [/SUP], Sergiu Groppa[SUP] #[/SUP][SUP] 2 [/SUP], Jonas A Hosp[SUP] #[/SUP][SUP] 3 [/SUP]
Affiliations
Objective: To investigate whether choroid plexus volumes in subacute coronavirus disease 2019 (COVID-19) patients with neurological symptoms could indicate inflammatory activation or barrier dysfunction and assess their association with clinical data.
Methods: Choroid plexus volumes were measured in 28 subacute COVID-19 patients via cerebral magnetic resonance imaging (MRI), compared with those in infection-triggered non-COVID-19 encephalopathy patients (n = 25), asymptomatic individuals after COVID-19 (n = 21), and healthy controls (n = 21). Associations with inflammatory serum markers (peak counts of leukocytes, C-reactive protein [CRP], interleukin 6), an MRI-based marker of barrier dysfunction (CSF volume fraction [V-CSF]), and clinical parameters like olfactory performance and cognitive scores (Montreal Cognitive Assessment) were investigated.
Results: COVID-19 patients showed significantly larger choroid plexus volumes than control groups (p < 0.001, η[SUP]2[/SUP] = 0.172). These volumes correlated significantly with peak leukocyte levels (p = 0.001, Pearson's r = 0.621) and V-CSF (p = 0.009, Spearman's rho = 0.534), but neither with CRP nor interleukin 6. No significant correlations were found with clinical parameters.
Interpretation: In patients with subacute COVID-19, choroid plexus volume is a marker of central nervous system inflammation and barrier dysfunction in the presence of neurologic symptoms. The absence of plexus enlargement in infection-triggered non-COVID-19 encephalopathy suggests a specific severe acute respiratory syndrome coronavirus 2 effect. This study also documents an increase in choroid plexus volume for the first time as a parainfectious event. ANN NEUROL 2024.
. 2024 Jun 27.
doi: 10.1002/ana.27016. Online ahead of print. Inflammation-Triggered Enlargement of Choroid Plexus in Subacute COVID-19 Patients with Neurological Symptoms
Alexander Rau[SUP] #[/SUP][SUP] 1 [/SUP], Gabriel Gonzalez-Escamilla[SUP] #[/SUP][SUP] 2 [/SUP], Nils Schroeter[SUP] 3 [/SUP], Ahmed Othmann[SUP] 4 [/SUP], Andrea Dressing[SUP] 3 [/SUP], Cornelius Weiller[SUP] 3 [/SUP], Horst Urbach[SUP] 1 [/SUP], Marco Reisert[SUP] 5 6 [/SUP], Sergiu Groppa[SUP] #[/SUP][SUP] 2 [/SUP], Jonas A Hosp[SUP] #[/SUP][SUP] 3 [/SUP]
Affiliations
- PMID: 38934493
- DOI: 10.1002/ana.27016
Objective: To investigate whether choroid plexus volumes in subacute coronavirus disease 2019 (COVID-19) patients with neurological symptoms could indicate inflammatory activation or barrier dysfunction and assess their association with clinical data.
Methods: Choroid plexus volumes were measured in 28 subacute COVID-19 patients via cerebral magnetic resonance imaging (MRI), compared with those in infection-triggered non-COVID-19 encephalopathy patients (n = 25), asymptomatic individuals after COVID-19 (n = 21), and healthy controls (n = 21). Associations with inflammatory serum markers (peak counts of leukocytes, C-reactive protein [CRP], interleukin 6), an MRI-based marker of barrier dysfunction (CSF volume fraction [V-CSF]), and clinical parameters like olfactory performance and cognitive scores (Montreal Cognitive Assessment) were investigated.
Results: COVID-19 patients showed significantly larger choroid plexus volumes than control groups (p < 0.001, η[SUP]2[/SUP] = 0.172). These volumes correlated significantly with peak leukocyte levels (p = 0.001, Pearson's r = 0.621) and V-CSF (p = 0.009, Spearman's rho = 0.534), but neither with CRP nor interleukin 6. No significant correlations were found with clinical parameters.
Interpretation: In patients with subacute COVID-19, choroid plexus volume is a marker of central nervous system inflammation and barrier dysfunction in the presence of neurologic symptoms. The absence of plexus enlargement in infection-triggered non-COVID-19 encephalopathy suggests a specific severe acute respiratory syndrome coronavirus 2 effect. This study also documents an increase in choroid plexus volume for the first time as a parainfectious event. ANN NEUROL 2024.