tetano
Editor, Senior Moderator
Ann Neurol
. 2020 Dec 9.
doi: 10.1002/ana.25987. Online ahead of print.
Incidence, clinical characteristics, risk factors and outcomes of Guillain-Barr? syndrome in patients with Covid-19
Marcos Fragiel[SUP] 1 [/SUP], ?scar Mir?[SUP] 2 [/SUP], Pere Llorens[SUP] 3 [/SUP], S?nia Jim?nez[SUP] 2 [/SUP], Pascual Pi?era[SUP] 4 [/SUP], Guillermo Burillo[SUP] 5 [/SUP], Alfonso Mart?n[SUP] 6 [/SUP], Francisco Javier Mart?n-S?nchez[SUP] 1 [/SUP], Eric Jorge Garc?a Lamberechts[SUP] 1 [/SUP], Javier Jacob[SUP] 7 [/SUP], Aitor Alqu?zar-Arb?[SUP] 8 [/SUP], Ricardo Ju?rez[SUP] 9 [/SUP], Blas Jim?nez[SUP] 10 [/SUP], Rigoberto Del Rio[SUP] 11 [/SUP], Miriam Mateo Roca[SUP] 12 [/SUP], Arturo Huerta Garc?a[SUP] 13 [/SUP], Nieves L?pez Laguna[SUP] 14 [/SUP], Mar?a Pilar L?pez D?ez[SUP] 15 [/SUP], Jorge Pedraza Garc?a[SUP] 16 [/SUP], Amparo Fern?ndez de Sim?n Almela[SUP] 17 [/SUP], Juan Jos? L?pez D?az[SUP] 18 [/SUP], Patricia Eiroa Hern?ndez[SUP] 19 [/SUP], Noem? Ruiz de Lobera[SUP] 20 [/SUP], Jes?s Porta-Etessam[SUP] 21 [/SUP], Cristina Fern?ndez P?rez[SUP] 22 [/SUP], Elpidio Calvo[SUP] 23 [/SUP], Juan Gonz?lez Del Castillo[SUP] 1 [/SUP], Spanish Investigators on Emergency Situations TeAm (SIESTA) network
Collaborators, Affiliations
Abstract
We diagnosed 11 Guillain-Barre syndrome (GBS) cases among 71,904 COVID patients attended at 61 Spanish emergency departments (ED) during the 2-month pandemic peak. The relative frequency of GBS among ED patients was higher in COVID (0.15‰) than non-COVID(0.02‰) patients (OR=6.30, 95%CI=3.18-12.5) as was the standardized incidence (9.44 and 0.69 cases/100,000-year, respectively, OR=13.5; 95%CI=9.87-18.4). Regarding clinical characteristics, olfactory-gustatory disorders were more frequent in COVID-GBS than non-COVID-GBS (OR=27.59, 95%CI=1.296-587) and COVID-non-GBS (OR=7.875, 95%CI=1.587-39.09) patients. Although COVID-GBS patients were more frequently admitted to intensive care, mortality was not increased versus control groups. Our results suggest SARS-CoV-2 could be another viral infection causing GBS. This article is protected by copyright. All rights reserved.
Keywords: Polyradiculoneuropathy; SARS-CoV-2 infection; coronavirus infections; nervous system diseases; neuromuscular diseases; peripheral nervous system diseases.
. 2020 Dec 9.
doi: 10.1002/ana.25987. Online ahead of print.
Incidence, clinical characteristics, risk factors and outcomes of Guillain-Barr? syndrome in patients with Covid-19
Marcos Fragiel[SUP] 1 [/SUP], ?scar Mir?[SUP] 2 [/SUP], Pere Llorens[SUP] 3 [/SUP], S?nia Jim?nez[SUP] 2 [/SUP], Pascual Pi?era[SUP] 4 [/SUP], Guillermo Burillo[SUP] 5 [/SUP], Alfonso Mart?n[SUP] 6 [/SUP], Francisco Javier Mart?n-S?nchez[SUP] 1 [/SUP], Eric Jorge Garc?a Lamberechts[SUP] 1 [/SUP], Javier Jacob[SUP] 7 [/SUP], Aitor Alqu?zar-Arb?[SUP] 8 [/SUP], Ricardo Ju?rez[SUP] 9 [/SUP], Blas Jim?nez[SUP] 10 [/SUP], Rigoberto Del Rio[SUP] 11 [/SUP], Miriam Mateo Roca[SUP] 12 [/SUP], Arturo Huerta Garc?a[SUP] 13 [/SUP], Nieves L?pez Laguna[SUP] 14 [/SUP], Mar?a Pilar L?pez D?ez[SUP] 15 [/SUP], Jorge Pedraza Garc?a[SUP] 16 [/SUP], Amparo Fern?ndez de Sim?n Almela[SUP] 17 [/SUP], Juan Jos? L?pez D?az[SUP] 18 [/SUP], Patricia Eiroa Hern?ndez[SUP] 19 [/SUP], Noem? Ruiz de Lobera[SUP] 20 [/SUP], Jes?s Porta-Etessam[SUP] 21 [/SUP], Cristina Fern?ndez P?rez[SUP] 22 [/SUP], Elpidio Calvo[SUP] 23 [/SUP], Juan Gonz?lez Del Castillo[SUP] 1 [/SUP], Spanish Investigators on Emergency Situations TeAm (SIESTA) network
Collaborators, Affiliations
- PMID: 33295021
- DOI: 10.1002/ana.25987
Abstract
We diagnosed 11 Guillain-Barre syndrome (GBS) cases among 71,904 COVID patients attended at 61 Spanish emergency departments (ED) during the 2-month pandemic peak. The relative frequency of GBS among ED patients was higher in COVID (0.15‰) than non-COVID(0.02‰) patients (OR=6.30, 95%CI=3.18-12.5) as was the standardized incidence (9.44 and 0.69 cases/100,000-year, respectively, OR=13.5; 95%CI=9.87-18.4). Regarding clinical characteristics, olfactory-gustatory disorders were more frequent in COVID-GBS than non-COVID-GBS (OR=27.59, 95%CI=1.296-587) and COVID-non-GBS (OR=7.875, 95%CI=1.587-39.09) patients. Although COVID-GBS patients were more frequently admitted to intensive care, mortality was not increased versus control groups. Our results suggest SARS-CoV-2 could be another viral infection causing GBS. This article is protected by copyright. All rights reserved.
Keywords: Polyradiculoneuropathy; SARS-CoV-2 infection; coronavirus infections; nervous system diseases; neuromuscular diseases; peripheral nervous system diseases.