tetano
Editor, Senior Moderator
Ann Med
. 2021 Dec;53(1):770-776.
doi: 10.1080/07853890.2021.1931957.
Effects of hypertension on the outcomes of COVID-19: a multicentre retrospective cohort study
Li Zhong[SUP] 1 [/SUP], Yuting Wu[SUP] 2 [/SUP], Jinghua Gao[SUP] 3 [/SUP], Jinxia Zhang[SUP] 4 [/SUP], Qifeng Xie[SUP] 5 [/SUP], Huang He[SUP] 6 [/SUP], Jingjing Ji[SUP] 3 [/SUP], Zheying Liu[SUP] 3 [/SUP], Conglin Wang[SUP] 3 [/SUP], Zhifeng Liu[SUP] 3 7 [/SUP]
Affiliations
Abstract
Objectives: Hypertension is thought to be a contributor to mortality in coronavirus disease 2019 patients; however, limited clinical data on the outcomes of COVID-19 in patients with hypertension are available.Methods: This study was designed to confirm whether hypertension affects the outcomes of COVID-19. Results: A total of 983 patients with COVID-19 (female, 48%; male, 52%) were enrolled. Significantly higher odds of 60-day mortality (p = .017) were observed in the hypertensive group. In the hypertensive group, even after adjustment in multivariate analysis, the subgroup of patients 70 years old and older had higher 28-day mortality and total 60-day mortality rates than the other age subgroups (bothp < .05). A total of 297 (89%) COVID-19 patients with hypertension survived, and 35 (11%) died. In addition, compared with hypertensive patients who survived COVID-19, non-survivors had more pre-existing conditions, including cardiovascular diseases and stroke, higher blood pressure on admission, more severe inflammation, and more liver and kidney damage.Conclusion: Hypertension does not affect the outcome of COVID-19, which is different than the conclusions drawn in other studies. However, the 28-day mortality and total 60-day mortality rates of hypertensive patients (age ≥ 70) with COVID-19 were significantly elevated, and compared with the group of survivors, non-surviving COVID-19 patients with hypertension were older, had more basic diseases and had a more severe clinical condition.
Keywords: COVID-19; age; clinical characteristics; hypertension; mortality.
. 2021 Dec;53(1):770-776.
doi: 10.1080/07853890.2021.1931957.
Effects of hypertension on the outcomes of COVID-19: a multicentre retrospective cohort study
Li Zhong[SUP] 1 [/SUP], Yuting Wu[SUP] 2 [/SUP], Jinghua Gao[SUP] 3 [/SUP], Jinxia Zhang[SUP] 4 [/SUP], Qifeng Xie[SUP] 5 [/SUP], Huang He[SUP] 6 [/SUP], Jingjing Ji[SUP] 3 [/SUP], Zheying Liu[SUP] 3 [/SUP], Conglin Wang[SUP] 3 [/SUP], Zhifeng Liu[SUP] 3 7 [/SUP]
Affiliations
- PMID: 34080499
- DOI: 10.1080/07853890.2021.1931957
Abstract
Objectives: Hypertension is thought to be a contributor to mortality in coronavirus disease 2019 patients; however, limited clinical data on the outcomes of COVID-19 in patients with hypertension are available.Methods: This study was designed to confirm whether hypertension affects the outcomes of COVID-19. Results: A total of 983 patients with COVID-19 (female, 48%; male, 52%) were enrolled. Significantly higher odds of 60-day mortality (p = .017) were observed in the hypertensive group. In the hypertensive group, even after adjustment in multivariate analysis, the subgroup of patients 70 years old and older had higher 28-day mortality and total 60-day mortality rates than the other age subgroups (bothp < .05). A total of 297 (89%) COVID-19 patients with hypertension survived, and 35 (11%) died. In addition, compared with hypertensive patients who survived COVID-19, non-survivors had more pre-existing conditions, including cardiovascular diseases and stroke, higher blood pressure on admission, more severe inflammation, and more liver and kidney damage.Conclusion: Hypertension does not affect the outcome of COVID-19, which is different than the conclusions drawn in other studies. However, the 28-day mortality and total 60-day mortality rates of hypertensive patients (age ≥ 70) with COVID-19 were significantly elevated, and compared with the group of survivors, non-surviving COVID-19 patients with hypertension were older, had more basic diseases and had a more severe clinical condition.
Keywords: COVID-19; age; clinical characteristics; hypertension; mortality.