tetano
Editor, Senior Moderator
Ann Intensive Care
. 2022 Jul 10;12(1):64.
doi: 10.1186/s13613-022-01034-4.
Clinical status of patients 1 year after hospital discharge following recovery from COVID-19: a prospective cohort study
Dapeng Li[SUP] #[/SUP][SUP] 1 [/SUP], Xuejiao Liao[SUP] #[/SUP][SUP] 1 2 [/SUP], Zhenghua Ma[SUP] 2 [/SUP], Lina Zhang[SUP] 2 [/SUP], Jingke Dong[SUP] 2 [/SUP], Guoqin Zheng[SUP] 2 [/SUP], Mei Zi[SUP] 3 [/SUP], Wujian Peng[SUP] 4 [/SUP], Lanlan Wei[SUP] 1 [/SUP], Zhiyan Li[SUP] 5 [/SUP], Yingjun Kong[SUP] 3 [/SUP], Lifei Wang[SUP] 6 [/SUP], Dongjing Liu[SUP] 1 [/SUP], Fang Wang[SUP] 1 [/SUP], Qing He[SUP] 7 [/SUP], Guobao Li[SUP] 8 [/SUP], Zheng Zhang[SUP] 9 10 11 [/SUP], Lei Liu[SUP] 12 13 [/SUP]
Affiliations
Abstract
Background: The long-term clinical status of coronavirus disease 2019 (COVID-19) in recovered patients remains largely unknown. This prospective cohort study evaluated clinical status of COVID-19 and explored the associated risk factors.
Methods: At the outpatient visit, patients underwent routine blood tests, physical examinations, pulmonary function tests, 6-min walk test, high-resolution computed tomography (CT) of the chest, and extrapulmonary organ function tests.
Results: 230 patients were analyzed. Half (52.7%) reported at least one symptom, most commonly fatigue (20.3%) and sleep difficulties (15.8%). Anxiety (8.2%), depression (11.3%), post-traumatic symptoms (10.3%), and sleep disorders (26.3%) were also reported. Diffusion impairments were found in 35.4% of the patients. Abnormal chest CT scans were present in 63.5% of the patients, mainly reticulation and ground-glass opacities. Further, a persistent decline in kidney function was observed after discharge. SARS-CoV-2-specific antibodies of IgA, IgG, and IgM were positive in 56.4%, 96.3%, and 15.2% of patients, respectively. Multivariable logistic regression showed that disease severity, age, and sex were closely related to patient recovery.
Conclusions: One year after hospital discharge, patients recovered from COVID-19 continued to experience both pulmonary and extrapulmonary dysfunction. While paying attention to pulmonary manifestations of COVID-19, follow-up studies on extrapulmonary manifestations should be strengthened.
Keywords: COVID-19; Extrapulmonary dysfunction; Pulmonary dysfunction; Risk factor; SARS-CoV-2 antibodies.
. 2022 Jul 10;12(1):64.
doi: 10.1186/s13613-022-01034-4.
Clinical status of patients 1 year after hospital discharge following recovery from COVID-19: a prospective cohort study
Dapeng Li[SUP] #[/SUP][SUP] 1 [/SUP], Xuejiao Liao[SUP] #[/SUP][SUP] 1 2 [/SUP], Zhenghua Ma[SUP] 2 [/SUP], Lina Zhang[SUP] 2 [/SUP], Jingke Dong[SUP] 2 [/SUP], Guoqin Zheng[SUP] 2 [/SUP], Mei Zi[SUP] 3 [/SUP], Wujian Peng[SUP] 4 [/SUP], Lanlan Wei[SUP] 1 [/SUP], Zhiyan Li[SUP] 5 [/SUP], Yingjun Kong[SUP] 3 [/SUP], Lifei Wang[SUP] 6 [/SUP], Dongjing Liu[SUP] 1 [/SUP], Fang Wang[SUP] 1 [/SUP], Qing He[SUP] 7 [/SUP], Guobao Li[SUP] 8 [/SUP], Zheng Zhang[SUP] 9 10 11 [/SUP], Lei Liu[SUP] 12 13 [/SUP]
Affiliations
- PMID: 35816225
- DOI: 10.1186/s13613-022-01034-4
Abstract
Background: The long-term clinical status of coronavirus disease 2019 (COVID-19) in recovered patients remains largely unknown. This prospective cohort study evaluated clinical status of COVID-19 and explored the associated risk factors.
Methods: At the outpatient visit, patients underwent routine blood tests, physical examinations, pulmonary function tests, 6-min walk test, high-resolution computed tomography (CT) of the chest, and extrapulmonary organ function tests.
Results: 230 patients were analyzed. Half (52.7%) reported at least one symptom, most commonly fatigue (20.3%) and sleep difficulties (15.8%). Anxiety (8.2%), depression (11.3%), post-traumatic symptoms (10.3%), and sleep disorders (26.3%) were also reported. Diffusion impairments were found in 35.4% of the patients. Abnormal chest CT scans were present in 63.5% of the patients, mainly reticulation and ground-glass opacities. Further, a persistent decline in kidney function was observed after discharge. SARS-CoV-2-specific antibodies of IgA, IgG, and IgM were positive in 56.4%, 96.3%, and 15.2% of patients, respectively. Multivariable logistic regression showed that disease severity, age, and sex were closely related to patient recovery.
Conclusions: One year after hospital discharge, patients recovered from COVID-19 continued to experience both pulmonary and extrapulmonary dysfunction. While paying attention to pulmonary manifestations of COVID-19, follow-up studies on extrapulmonary manifestations should be strengthened.
Keywords: COVID-19; Extrapulmonary dysfunction; Pulmonary dysfunction; Risk factor; SARS-CoV-2 antibodies.