tetano
Editor, Senior Moderator
Ann Hepatol
. 2020 Nov 3;S1665-2681(20)30204-0.
doi: 10.1016/j.aohep.2020.10.007. Online ahead of print.
Prognostic value of liver biochemical parameters for COVID-19 mortality
Lin Ye[SUP] 1 [/SUP], Bin Chen[SUP] 2 [/SUP], Yitong Wang[SUP] 3 [/SUP], Yi Yang[SUP] 1 [/SUP], Jiling Zeng[SUP] 4 [/SUP], Guangtong Deng[SUP] 1 [/SUP], Yuhao Deng[SUP] 5 [/SUP], Furong Zeng[SUP] 6 [/SUP]
Affiliations
Abstract
Introduction: Coronavirus Disease 2019 (COVID-19) has brought great challenges to global public health. However, a comprehensive analysis of the relationship between liver biochemical parameters and COVID-19 mortality is quite limited.
Methods: We searched the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science, Scopus, Wanfang and China National Knowledge Infrastructure database until May 5, 2020. STATA software was used for the statistical analyses.
Results: A total of 25 studies involving 5971 COVID-19 patients were included in our analysis. Compared with non-survivors, survivors had lower levels of aspartate aminotransferase (AST) (weighted mean difference [WMD]=-16.71U/L, 95%CI=[-21.03, -12.40], P<0.001), alanine transaminase (ALT) (WMD=-5.20U/L, 95%CI=[-8.00, -2.41], P<0.001), total bilirubin (TBIL) (WMD=4.40μmol/L, 95%CI=[-5.11, -3.70], P<0.001) and lactic dehydrogenase (LDH) (WMD=-252.44U/L, 95%CI=[-289.57, -215.30], P<0.001), and higher albumin (ALB) level (WMD=4.47g/L, 95%CI=[3.47, 5.47], P<0.001). Besides, survivors had lower proportions of these abnormally increased parameters (AST: OR=0.25, 95%CI=[0.15, 0.41], P<0.001; ALT: OR=0.49, 95%CI=[0.37, 0.64], P<0.001; TBIL: (OR=0.20, 95%CI=[0.12, 0.34], P<0.001; LDH, OR=0.09, 95%CI=[0.06, 0.14], P<0.001), and lower proportion of abnormally decreased ALB (OR=0.16, 95%CI=[0.07, 0.38], P<0.001). Meta-analysis based on standard mean difference and sensitivity analysis did not change the conclusions. Egger test did not detect the presence of publication bias.
Conclusions: Liver biochemical parameters were strongly correlated with COVID-19 mortality. Measurement of these liver biochemical parameters might assist clinicians to evaluate the prognosis of COVID-19.
Keywords: COVID-19; Liver biochemical parameters; Meta-analysis.; Mortality.
. 2020 Nov 3;S1665-2681(20)30204-0.
doi: 10.1016/j.aohep.2020.10.007. Online ahead of print.
Prognostic value of liver biochemical parameters for COVID-19 mortality
Lin Ye[SUP] 1 [/SUP], Bin Chen[SUP] 2 [/SUP], Yitong Wang[SUP] 3 [/SUP], Yi Yang[SUP] 1 [/SUP], Jiling Zeng[SUP] 4 [/SUP], Guangtong Deng[SUP] 1 [/SUP], Yuhao Deng[SUP] 5 [/SUP], Furong Zeng[SUP] 6 [/SUP]
Affiliations
- PMID: 33157267
- DOI: 10.1016/j.aohep.2020.10.007
Abstract
Introduction: Coronavirus Disease 2019 (COVID-19) has brought great challenges to global public health. However, a comprehensive analysis of the relationship between liver biochemical parameters and COVID-19 mortality is quite limited.
Methods: We searched the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science, Scopus, Wanfang and China National Knowledge Infrastructure database until May 5, 2020. STATA software was used for the statistical analyses.
Results: A total of 25 studies involving 5971 COVID-19 patients were included in our analysis. Compared with non-survivors, survivors had lower levels of aspartate aminotransferase (AST) (weighted mean difference [WMD]=-16.71U/L, 95%CI=[-21.03, -12.40], P<0.001), alanine transaminase (ALT) (WMD=-5.20U/L, 95%CI=[-8.00, -2.41], P<0.001), total bilirubin (TBIL) (WMD=4.40μmol/L, 95%CI=[-5.11, -3.70], P<0.001) and lactic dehydrogenase (LDH) (WMD=-252.44U/L, 95%CI=[-289.57, -215.30], P<0.001), and higher albumin (ALB) level (WMD=4.47g/L, 95%CI=[3.47, 5.47], P<0.001). Besides, survivors had lower proportions of these abnormally increased parameters (AST: OR=0.25, 95%CI=[0.15, 0.41], P<0.001; ALT: OR=0.49, 95%CI=[0.37, 0.64], P<0.001; TBIL: (OR=0.20, 95%CI=[0.12, 0.34], P<0.001; LDH, OR=0.09, 95%CI=[0.06, 0.14], P<0.001), and lower proportion of abnormally decreased ALB (OR=0.16, 95%CI=[0.07, 0.38], P<0.001). Meta-analysis based on standard mean difference and sensitivity analysis did not change the conclusions. Egger test did not detect the presence of publication bias.
Conclusions: Liver biochemical parameters were strongly correlated with COVID-19 mortality. Measurement of these liver biochemical parameters might assist clinicians to evaluate the prognosis of COVID-19.
Keywords: COVID-19; Liver biochemical parameters; Meta-analysis.; Mortality.