tetano
Editor, Senior Moderator
Ann Hematol
. 2020 Jun 3.
doi: 10.1007/s00277-020-04103-5. Online ahead of print.
Hematological Findings in Coronavirus Disease 2019: Indications of Progression of Disease
Xiaoqing Liu[SUP] 1 [/SUP], Run Zhang[SUP] 1 [/SUP], Guangsheng He[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a new human infectious disease. The etiology for this outbreak is a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus far, related research on COVID-19 is still in preliminary stage. This paper summarized the latest outcomes of corresponding study from Chinese centers and clarified the hematopoietic abnormality caused by SARS-CoV-2 and potential mechanism. Lymphopenia was common in the early stage after the onset of COVID-19. A significant decrease was observed in peripheral CD4+ and CD8+ T lymphocytes. As the illness progressed, neutrophilia emerged in several cases, and patients with severe critical pulmonary conditions showed higher neutrophils than common type. Thrombocytopenia was resulting from the consumption and/or the reduced production of platelets in damaged lungs. Anemia was not observed notably, but the decrease in hemoglobin was frequent. The activation of monocyte-macrophage system aggravates the immune damage of lung and other tissues, which leads to the increase of D-dimer, prothrombin time, and platelet consumption.
Keywords: COVID-19; Hemoglobin; Lymphopenia; Neutrophilia; SARS-CoV-2; Thrombocytopenia.
. 2020 Jun 3.
doi: 10.1007/s00277-020-04103-5. Online ahead of print.
Hematological Findings in Coronavirus Disease 2019: Indications of Progression of Disease
Xiaoqing Liu[SUP] 1 [/SUP], Run Zhang[SUP] 1 [/SUP], Guangsheng He[SUP] 2 [/SUP]
Affiliations
- PMID: 32495027
- DOI: 10.1007/s00277-020-04103-5
Abstract
Coronavirus disease 2019 (COVID-19) is a new human infectious disease. The etiology for this outbreak is a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus far, related research on COVID-19 is still in preliminary stage. This paper summarized the latest outcomes of corresponding study from Chinese centers and clarified the hematopoietic abnormality caused by SARS-CoV-2 and potential mechanism. Lymphopenia was common in the early stage after the onset of COVID-19. A significant decrease was observed in peripheral CD4+ and CD8+ T lymphocytes. As the illness progressed, neutrophilia emerged in several cases, and patients with severe critical pulmonary conditions showed higher neutrophils than common type. Thrombocytopenia was resulting from the consumption and/or the reduced production of platelets in damaged lungs. Anemia was not observed notably, but the decrease in hemoglobin was frequent. The activation of monocyte-macrophage system aggravates the immune damage of lung and other tissues, which leads to the increase of D-dimer, prothrombin time, and platelet consumption.
Keywords: COVID-19; Hemoglobin; Lymphopenia; Neutrophilia; SARS-CoV-2; Thrombocytopenia.