tetano
Editor, Senior Moderator
Ann Epidemiol
. 2025 Jan 21:S1047-2797(25)00012-2.
doi: 10.1016/j.annepidem.2025.01.006. Online ahead of print. Associations of Pregnancy Timing Relative to the COVID-19 Pandemic, Maternal SARS-CoV-2 Infection, and Adverse Perinatal Outcomes
Maria Sevoyan[SUP] 1 [/SUP], Jihong Liu[SUP] 2 [/SUP], Yi-Wen Shih[SUP] 3 [/SUP], Peiyin Hung[SUP] 4 [/SUP], Jiajia Zhang[SUP] 5 [/SUP], Xiaoming Li[SUP] 6 [/SUP]
Affiliations
Purpose: To examine associations between COVID-19 pandemic and maternal SARS-CoV-2 infection with perinatal outcomes.
Methods: We conducted a retrospective cohort study of 189,097 singleton births in South Carolina (2018-2021). Pregnancy timing relative to the pandemic was classified as pre-pandemic (delivered before March 1, 2020), partial pandemic overlap (conceived before and delivered during the pandemic), or pandemic (conceived and delivered during the pandemic). We examined COVID-19 testing, severity, and timing. Modified Poisson regression models with robust variance were used.
Results: Compared to pre-pandemic group, the partial overlap group had lower risks of low birthweight (LBW) (aRR=0.93, 95% CI 0.89-0.97) and preterm birth (PTB) (aRR=0.91, 95% CI 0.88-0.95). The pandemic group had increased risks for LBW (aRR=1.10, 95% CI 1.06-1.14), PTB (aRR=1.10, 95% CI 1.07-1.14), and NICU admissions (aRR=1.13, 95% CI 1.09-1.17) but a decreased risk for breastfeeding initiation (aRR=0.98, 95% CI 0.97-0.98). Moderate-to-severe COVID-19 symptoms increased PTB (aRR=1.34, 95% CI 1.13-1.58). Third-trimester COVID-19 infection increased LBW (aRR=1.23, 95% CI 1.10-1.37), PTB (aRR=1.18, 95% CI 1.07-1.30), and NICU admissions (aRR=1.17, 95% CI 1.05-1.30).
Conclusions: Our findings highlight the importance of considering both maternal COVID-19 infection and pandemic-related factors in optimizing perinatal outcomes.
Keywords: Breastfeeding initiation; Coronavirus; NICU admission; low birthweight; perinatal outcomes; preterm birth.
. 2025 Jan 21:S1047-2797(25)00012-2.
doi: 10.1016/j.annepidem.2025.01.006. Online ahead of print. Associations of Pregnancy Timing Relative to the COVID-19 Pandemic, Maternal SARS-CoV-2 Infection, and Adverse Perinatal Outcomes
Maria Sevoyan[SUP] 1 [/SUP], Jihong Liu[SUP] 2 [/SUP], Yi-Wen Shih[SUP] 3 [/SUP], Peiyin Hung[SUP] 4 [/SUP], Jiajia Zhang[SUP] 5 [/SUP], Xiaoming Li[SUP] 6 [/SUP]
Affiliations
- PMID: 39848480
- DOI: 10.1016/j.annepidem.2025.01.006
Purpose: To examine associations between COVID-19 pandemic and maternal SARS-CoV-2 infection with perinatal outcomes.
Methods: We conducted a retrospective cohort study of 189,097 singleton births in South Carolina (2018-2021). Pregnancy timing relative to the pandemic was classified as pre-pandemic (delivered before March 1, 2020), partial pandemic overlap (conceived before and delivered during the pandemic), or pandemic (conceived and delivered during the pandemic). We examined COVID-19 testing, severity, and timing. Modified Poisson regression models with robust variance were used.
Results: Compared to pre-pandemic group, the partial overlap group had lower risks of low birthweight (LBW) (aRR=0.93, 95% CI 0.89-0.97) and preterm birth (PTB) (aRR=0.91, 95% CI 0.88-0.95). The pandemic group had increased risks for LBW (aRR=1.10, 95% CI 1.06-1.14), PTB (aRR=1.10, 95% CI 1.07-1.14), and NICU admissions (aRR=1.13, 95% CI 1.09-1.17) but a decreased risk for breastfeeding initiation (aRR=0.98, 95% CI 0.97-0.98). Moderate-to-severe COVID-19 symptoms increased PTB (aRR=1.34, 95% CI 1.13-1.58). Third-trimester COVID-19 infection increased LBW (aRR=1.23, 95% CI 1.10-1.37), PTB (aRR=1.18, 95% CI 1.07-1.30), and NICU admissions (aRR=1.17, 95% CI 1.05-1.30).
Conclusions: Our findings highlight the importance of considering both maternal COVID-19 infection and pandemic-related factors in optimizing perinatal outcomes.
Keywords: Breastfeeding initiation; Coronavirus; NICU admission; low birthweight; perinatal outcomes; preterm birth.