tetano
Editor, Senior Moderator
Ann Clin Transl Neurol
. 2021 Jul 11.
doi: 10.1002/acn3.51416. Online ahead of print.
Diaphragm dysfunction in severe COVID-19 as determined by neuromuscular ultrasound
Ellen Farr[SUP] 1 2 3 [/SUP], Alexis R Wolfe[SUP] 1 4 [/SUP], Swati Deshmukh[SUP] 5 [/SUP], Leslie Rydberg[SUP] 2 3 [/SUP], Rachna Soriano[SUP] 2 3 [/SUP], James M Walter[SUP] 4 [/SUP], Andrea J Boon[SUP] 6 7 [/SUP], Lisa F Wolfe[SUP] 4 8 [/SUP], Colin K Franz[SUP] 2 3 8 [/SUP]
Affiliations
Abstract
Many survivors from severe coronavirus disease 2019 (COVID-19) suffer from persistent dyspnea and fatigue long after resolution of the active infection. In a cohort of 21 consecutive severe post-COVID-19 survivors admitted to an inpatient rehabilitation hospital, 16 (76%) of them had at least one sonographic abnormality of diaphragm muscle structure or function. This corresponded to a significant reduction in diaphragm muscle contractility as represented by thickening ratio (muscle thickness at maximal inspiration/end-expiration) for the post-COVID-19 compared to non-COVID-19 cohorts. These findings may shed new light on neuromuscular respiratory dysfunction as a contributor to prolonged functional impairments after hospitalization for post-COVID-19.
. 2021 Jul 11.
doi: 10.1002/acn3.51416. Online ahead of print.
Diaphragm dysfunction in severe COVID-19 as determined by neuromuscular ultrasound
Ellen Farr[SUP] 1 2 3 [/SUP], Alexis R Wolfe[SUP] 1 4 [/SUP], Swati Deshmukh[SUP] 5 [/SUP], Leslie Rydberg[SUP] 2 3 [/SUP], Rachna Soriano[SUP] 2 3 [/SUP], James M Walter[SUP] 4 [/SUP], Andrea J Boon[SUP] 6 7 [/SUP], Lisa F Wolfe[SUP] 4 8 [/SUP], Colin K Franz[SUP] 2 3 8 [/SUP]
Affiliations
- PMID: 34247452
- DOI: 10.1002/acn3.51416
Abstract
Many survivors from severe coronavirus disease 2019 (COVID-19) suffer from persistent dyspnea and fatigue long after resolution of the active infection. In a cohort of 21 consecutive severe post-COVID-19 survivors admitted to an inpatient rehabilitation hospital, 16 (76%) of them had at least one sonographic abnormality of diaphragm muscle structure or function. This corresponded to a significant reduction in diaphragm muscle contractility as represented by thickening ratio (muscle thickness at maximal inspiration/end-expiration) for the post-COVID-19 compared to non-COVID-19 cohorts. These findings may shed new light on neuromuscular respiratory dysfunction as a contributor to prolonged functional impairments after hospitalization for post-COVID-19.