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Ann Clin Microbiol Antimicrob Ivermectin, a New Candidate Therapeutic Against SARS-CoV-2/COVID-19

tetano

tetano

Editor, Senior Moderator
Ann Clin Microbiol Antimicrob


. 2020 May 30;19(1):23.
doi: 10.1186/s12941-020-00368-w.
Ivermectin, a New Candidate Therapeutic Against SARS-CoV-2/COVID-19


Khan Sharun[SUP] 1 [/SUP], Kuldeep Dhama[SUP] 2 [/SUP], Shailesh Kumar Patel[SUP] 3 [/SUP], Mamta Pathak[SUP] 3 [/SUP], Ruchi Tiwari[SUP] 4 [/SUP], Bhoj Raj Singh[SUP] 5 [/SUP], Ranjit Sah[SUP] 6 [/SUP], D Katterine Bonilla-Aldana[SUP] 7 8 [/SUP], Alfonso J Rodriguez-Morales[SUP] 9 10 [/SUP], Hakan Leblebicioglu[SUP] 11 [/SUP]



Affiliations
Free PMC article
 
Citation from the study:

Hence, we can conclude the following:
  • Ivermectin exerts broad-spectrum antiviral activity against several animal and human viruses, including both RNA and DNA viruses.
  • The antiviral potential of ivermectin against various viruses is mediated via the targeting of the following: importin α/β-mediated nuclear transport of HIV-1 integrase and NS5 polymerase; NS3 helicase; nuclear import of UL42; and nuclear localization signal-mediated nuclear import of Cap.
  • As SARS-CoV-2 is an RNA virus, the antiviral activity of ivermectin may be mediated through the inhibition of importin α/β-mediated nuclear transport of viral proteins.
  • The clinical efficacy and utility of ivermectin in SARS-CoV-2-infected patients are unpredictable at this stage, as we are dealing with a completely novel virus.
 
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