tetano
Editor, Senior Moderator
Ann Agric Environ Med
. 2020 Jun 19;27(2):317-318.
doi: 10.26444/aaem/123543. Epub 2020 Jun 19.
A 56-year-old Man With RT-PCR Negative Nasopharyngeal Swabs With Coronavirus Disease 2019 (COVID-19) Pneumonia
Anna Dworzańska[SUP] 1 [/SUP], Magdalena Tudrujek-Zdunek[SUP] 1 [/SUP], Jerzy Mosiewicz[SUP] 2 [/SUP], Lech Panasiuk[SUP] 3 [/SUP], Krzysztof Tomasiewicz[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: Diagnostic procedure in Coronavirus Disease 2019 (COVID-19) is based mainly on performing real-time-reverse transcription-polymerase chain-reaction (RT-PCR), which has been accepted as the gold standard method. In some cases, such as mutations of the SARS-CoV-2 genome, variable viral load kinetics or laboratory errors, it can be false-negative.
Case report: The case is presented of a 56-year-old man with respiratory tract symptoms, with twice negative results of real-time-reverse transcription-polymerase chain-reaction of nasopharyngeal swabs and positive chest computed tomography, with typical findings for COVID-19 pneumonia.
Conclusions: Patients with negative RT-PCR results, but with positive computed tomography findings characteristic for COVID-19, should be treated as well as those infected.
Keywords: COVID-19; Coronavirus Disease 2019; RT-PCR; chest computed tomography; pneumonia; real-time-reverse transcription-polymerase chain-reaction.
. 2020 Jun 19;27(2):317-318.
doi: 10.26444/aaem/123543. Epub 2020 Jun 19.
A 56-year-old Man With RT-PCR Negative Nasopharyngeal Swabs With Coronavirus Disease 2019 (COVID-19) Pneumonia
Anna Dworzańska[SUP] 1 [/SUP], Magdalena Tudrujek-Zdunek[SUP] 1 [/SUP], Jerzy Mosiewicz[SUP] 2 [/SUP], Lech Panasiuk[SUP] 3 [/SUP], Krzysztof Tomasiewicz[SUP] 1 [/SUP]
Affiliations
- PMID: 32588614
- DOI: 10.26444/aaem/123543
Abstract
Introduction: Diagnostic procedure in Coronavirus Disease 2019 (COVID-19) is based mainly on performing real-time-reverse transcription-polymerase chain-reaction (RT-PCR), which has been accepted as the gold standard method. In some cases, such as mutations of the SARS-CoV-2 genome, variable viral load kinetics or laboratory errors, it can be false-negative.
Case report: The case is presented of a 56-year-old man with respiratory tract symptoms, with twice negative results of real-time-reverse transcription-polymerase chain-reaction of nasopharyngeal swabs and positive chest computed tomography, with typical findings for COVID-19 pneumonia.
Conclusions: Patients with negative RT-PCR results, but with positive computed tomography findings characteristic for COVID-19, should be treated as well as those infected.
Keywords: COVID-19; Coronavirus Disease 2019; RT-PCR; chest computed tomography; pneumonia; real-time-reverse transcription-polymerase chain-reaction.