tetano
Editor, Senior Moderator
Angew Chem Int Ed Engl
. 2020 May 18.
doi: 10.1002/anie.202004832. Online ahead of print.
Reverse Design of an Influenza Neutralizing Spiky Nano-Inhibitor With a Dual Mode of Action
Chuanxiong Nie[SUP] 1 [/SUP], Badri Parshad[SUP] 2 [/SUP], Sumati Bhatia[SUP] 3 [/SUP], Chong Cheng[SUP] 4 [/SUP], Marlena Stadtm?ller[SUP] 5 [/SUP], Alexander Oehrl[SUP] 6 [/SUP], Yannic Kerkhoff[SUP] 6 [/SUP], Thorsten Wolff[SUP] 5 [/SUP], Rainer Haag[SUP] 7 [/SUP]
Affiliations
Abstract
In this study, we demonstrate the concept of 'reverse design' for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nano-inhibitor that has a reverse shape to the viral particle and heteromultivalent inhibitory effects on hemagglutinin and neuraminidase. The synthesized nano-inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to the host cells. The virus replication was significantly reduced by 6 orders of magnitude in the presence of the reverse designed nano-inhibitors. Even being used 24 hours after the infection, >99.999% inhibition is also achieved, which indicates such a nano-inhibitor might be a potent antiviral for the treatment of influenza infection.
Keywords: heteromultivalent inhibitor; influenza inhibition; matched nano-morphology; reverse design.
. 2020 May 18.
doi: 10.1002/anie.202004832. Online ahead of print.
Reverse Design of an Influenza Neutralizing Spiky Nano-Inhibitor With a Dual Mode of Action
Chuanxiong Nie[SUP] 1 [/SUP], Badri Parshad[SUP] 2 [/SUP], Sumati Bhatia[SUP] 3 [/SUP], Chong Cheng[SUP] 4 [/SUP], Marlena Stadtm?ller[SUP] 5 [/SUP], Alexander Oehrl[SUP] 6 [/SUP], Yannic Kerkhoff[SUP] 6 [/SUP], Thorsten Wolff[SUP] 5 [/SUP], Rainer Haag[SUP] 7 [/SUP]
Affiliations
- PMID: 32421225
- DOI: 10.1002/anie.202004832
Abstract
In this study, we demonstrate the concept of 'reverse design' for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nano-inhibitor that has a reverse shape to the viral particle and heteromultivalent inhibitory effects on hemagglutinin and neuraminidase. The synthesized nano-inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to the host cells. The virus replication was significantly reduced by 6 orders of magnitude in the presence of the reverse designed nano-inhibitors. Even being used 24 hours after the infection, >99.999% inhibition is also achieved, which indicates such a nano-inhibitor might be a potent antiviral for the treatment of influenza infection.
Keywords: heteromultivalent inhibitor; influenza inhibition; matched nano-morphology; reverse design.