tetano
Editor, Senior Moderator
Andrology
. 2020 Sep 22.
doi: 10.1111/andr.12907. Online ahead of print.
Coronavirus: A Possible Cause of Reduced Male Fertility
Chuan Huang[SUP] 1 2 [/SUP], Xiren Ji[SUP] 1 [/SUP], Wenjun Zhou[SUP] 1 [/SUP], Zhenghui Huang[SUP] 1 2 [/SUP], Xiangjie Peng[SUP] 2 [/SUP], Liqing Fan[SUP] 1 2 [/SUP], Ge Lin[SUP] 1 2 [/SUP], Wenbing Zhu[SUP] 1 2 [/SUP]
Affiliations
Abstract
In lately December 2019, a novel coronavirus (SARS-CoV-2) outbreak occurred in Wuhan, PR China. It is a high contagious virus that has threatened human health worldwide. SARS-CoV-2 infection, termed COVID-19, causes rapidly developing lung lesions that can lead to multiple organ failure in a short period. Whenever a novel virus emerges, reproductive risk assessments should be performed after infection. In this review, we show that male fertility might be damaged by coronavirus associated with (i) direct cytopathic effects derived from viral replication and viral dissemination in the testis; and (ii) indirect damage to male fertility derived from immunopathology. In this review, we briefly describe the impaired fertility of humans and animals infected with coronaviruses to deduce the impact of the new coronavirus on male fertility. Together with information related to other coronaviruses, we extrapolate this knowledge to the new coronavirus SARS-CoV-2, which may have a significant impact on our understanding of the pathophysiology of this new virus.
Keywords: Coronavirus; Fertility; Male; SARS-CoV-2; Testis.
. 2020 Sep 22.
doi: 10.1111/andr.12907. Online ahead of print.
Coronavirus: A Possible Cause of Reduced Male Fertility
Chuan Huang[SUP] 1 2 [/SUP], Xiren Ji[SUP] 1 [/SUP], Wenjun Zhou[SUP] 1 [/SUP], Zhenghui Huang[SUP] 1 2 [/SUP], Xiangjie Peng[SUP] 2 [/SUP], Liqing Fan[SUP] 1 2 [/SUP], Ge Lin[SUP] 1 2 [/SUP], Wenbing Zhu[SUP] 1 2 [/SUP]
Affiliations
- PMID: 32960504
- DOI: 10.1111/andr.12907
Abstract
In lately December 2019, a novel coronavirus (SARS-CoV-2) outbreak occurred in Wuhan, PR China. It is a high contagious virus that has threatened human health worldwide. SARS-CoV-2 infection, termed COVID-19, causes rapidly developing lung lesions that can lead to multiple organ failure in a short period. Whenever a novel virus emerges, reproductive risk assessments should be performed after infection. In this review, we show that male fertility might be damaged by coronavirus associated with (i) direct cytopathic effects derived from viral replication and viral dissemination in the testis; and (ii) indirect damage to male fertility derived from immunopathology. In this review, we briefly describe the impaired fertility of humans and animals infected with coronaviruses to deduce the impact of the new coronavirus on male fertility. Together with information related to other coronaviruses, we extrapolate this knowledge to the new coronavirus SARS-CoV-2, which may have a significant impact on our understanding of the pathophysiology of this new virus.
Keywords: Coronavirus; Fertility; Male; SARS-CoV-2; Testis.