tetano
Editor, Senior Moderator
Anal Methods
. 2023 Feb 1.
doi: 10.1039/d2ay01890j. Online ahead of print.
Development and validation of a mass spectrometry based analytical method to quantify the ratios in hemagglutinin trimers in quadrivalent influenza nanoparticle vaccine - FluMos-v1
Asif Shajahan[SUP] 1 [/SUP], Cindy X Cai[SUP] 1 [/SUP], Jeremy Wolff[SUP] 1 [/SUP], R Sylvie Yang[SUP] 1 [/SUP], Vera B Ivleva[SUP] 1 [/SUP], Daniel B Gowetski[SUP] 1 [/SUP], Jason G D Gall[SUP] 1 [/SUP], Q Paula Lei[SUP] 1 [/SUP]
Affiliations
Abstract
A quadrivalent influenza nanoparticle vaccine (FluMos-v1) offers long-lasting protection against multiple influenza virus strains and is composed of four strains of hemagglutinin trimer (HAT) assembled around a pentamer core. Here we report an LC-MS/MS analytical development and validation method to measure the percentage of each HAT component in FluMos-v1.
. 2023 Feb 1.
doi: 10.1039/d2ay01890j. Online ahead of print.
Development and validation of a mass spectrometry based analytical method to quantify the ratios in hemagglutinin trimers in quadrivalent influenza nanoparticle vaccine - FluMos-v1
Asif Shajahan[SUP] 1 [/SUP], Cindy X Cai[SUP] 1 [/SUP], Jeremy Wolff[SUP] 1 [/SUP], R Sylvie Yang[SUP] 1 [/SUP], Vera B Ivleva[SUP] 1 [/SUP], Daniel B Gowetski[SUP] 1 [/SUP], Jason G D Gall[SUP] 1 [/SUP], Q Paula Lei[SUP] 1 [/SUP]
Affiliations
- PMID: 36723411
- DOI: 10.1039/d2ay01890j
Abstract
A quadrivalent influenza nanoparticle vaccine (FluMos-v1) offers long-lasting protection against multiple influenza virus strains and is composed of four strains of hemagglutinin trimer (HAT) assembled around a pentamer core. Here we report an LC-MS/MS analytical development and validation method to measure the percentage of each HAT component in FluMos-v1.