tetano
Editor, Senior Moderator
An Pediatr (Engl Ed)
. 2021 Mar 24.
doi: 10.1016/j.anpede.2020.12.011. Online ahead of print.
Differential clinic in children infected by SARS-CoV-2, traceability of contacts and cost-effectiveness of diagnostic tests: Cross-sectional observational study
Antia Fiel-Ozores[SUP] 1 [/SUP], Mar?a Luisa Gonz?lez-Dur?n[SUP] 1 [/SUP], Reyes Novoa-Carballal[SUP] 1 [/SUP], Mar?a Del Mar Portugu?s-de la Red[SUP] 1 [/SUP], Isabel Fern?ndez-Pinilla[SUP] 1 [/SUP], Jorge Julio Cabrera-Alvargonz?lez[SUP] 2 [/SUP], Cristina Mart?nez-Reglero[SUP] 3 [/SUP], Sonia Rey-Cao[SUP] 2 [/SUP], Ana Concheiro-Guis?n[SUP] 1 [/SUP]
Affiliations
Abstract
in English, Spanish
Introduction: Given the possible coexistence of infection by the SARS-CoV-2 with other seasonal infections, the aim is to identify differential symptoms. I know has studied the role of children in intrafamily contagion and the sensitivity of reverse transcriptase polymerase chain reaction (RT-PCR) in an area with low community transmission.
Material and methods: Cross-sectional observational study. Patients between 0-15 years studied by RT-PCR technique due to clinical suspicion of infection by SARS-CoV-2 virus in the months of March-May 2020. Survey on symptoms and contacts. Determination of Anti-SARS-CoV-2 antibodies at least 21 days after the RT-PCR test.
Results: 126 patients were included, 33 with confirmed infection and age mean 8.4 years (95% CI 6.8-10.5) higher than not infected. Fever was the most common and with greater sensitivity. The differences found were a greater frequency of anosmia (P = .029) and headache (P = .009) among children infected with a specificity of 96.7% and 81.5% respectively. There were no differences in the duration of the symptoms. 81.8% of those infected were probably infected in the nucleus 85.2% by a parent who worked outside the home. The sensitivity of RT-PCR was 70.9% and its negative predictive value 91.1%.
Conclusions: The clinical picture is nonspecific and the symptoms more specific difficult to detect in younger children. Children had a reduced role in the intrafamily transmission. The sensitivity of RT-PCR could be related to a less contagiousness in children after one week of infection.
Keywords: COVID-19; Clinical features; Coronavirus; Epidemiology; Family transmission; Paediatrics; SARS-CoV-2.
. 2021 Mar 24.
doi: 10.1016/j.anpede.2020.12.011. Online ahead of print.
Differential clinic in children infected by SARS-CoV-2, traceability of contacts and cost-effectiveness of diagnostic tests: Cross-sectional observational study
Antia Fiel-Ozores[SUP] 1 [/SUP], Mar?a Luisa Gonz?lez-Dur?n[SUP] 1 [/SUP], Reyes Novoa-Carballal[SUP] 1 [/SUP], Mar?a Del Mar Portugu?s-de la Red[SUP] 1 [/SUP], Isabel Fern?ndez-Pinilla[SUP] 1 [/SUP], Jorge Julio Cabrera-Alvargonz?lez[SUP] 2 [/SUP], Cristina Mart?nez-Reglero[SUP] 3 [/SUP], Sonia Rey-Cao[SUP] 2 [/SUP], Ana Concheiro-Guis?n[SUP] 1 [/SUP]
Affiliations
- PMID: 33778108
- PMCID: PMC7988431
- DOI: 10.1016/j.anpede.2020.12.011
Abstract
in English, Spanish
Introduction: Given the possible coexistence of infection by the SARS-CoV-2 with other seasonal infections, the aim is to identify differential symptoms. I know has studied the role of children in intrafamily contagion and the sensitivity of reverse transcriptase polymerase chain reaction (RT-PCR) in an area with low community transmission.
Material and methods: Cross-sectional observational study. Patients between 0-15 years studied by RT-PCR technique due to clinical suspicion of infection by SARS-CoV-2 virus in the months of March-May 2020. Survey on symptoms and contacts. Determination of Anti-SARS-CoV-2 antibodies at least 21 days after the RT-PCR test.
Results: 126 patients were included, 33 with confirmed infection and age mean 8.4 years (95% CI 6.8-10.5) higher than not infected. Fever was the most common and with greater sensitivity. The differences found were a greater frequency of anosmia (P = .029) and headache (P = .009) among children infected with a specificity of 96.7% and 81.5% respectively. There were no differences in the duration of the symptoms. 81.8% of those infected were probably infected in the nucleus 85.2% by a parent who worked outside the home. The sensitivity of RT-PCR was 70.9% and its negative predictive value 91.1%.
Conclusions: The clinical picture is nonspecific and the symptoms more specific difficult to detect in younger children. Children had a reduced role in the intrafamily transmission. The sensitivity of RT-PCR could be related to a less contagiousness in children after one week of infection.
Keywords: COVID-19; Clinical features; Coronavirus; Epidemiology; Family transmission; Paediatrics; SARS-CoV-2.