sharon sanders
Editor-in-Chief & President
hat tip FluBossie
An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels
Middle East respiratory syndrome coronavirus (MERS-CoV) infections have led to an ongoing outbreak in humans, which was fueled by multiple zoonotic MERS-CoV introductions from dromedary camels. In addition to the implementation of hygiene measures to limit further camel-to-human and human-to-human transmissions, vaccine-mediated reduction of MERS-CoV spread from the animal reservoir may be envisaged. Here we show that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS-CoV spike protein confers mucosal immunity in dromedary camels.
Compared with results for control animals, we observed a significant reduction of excreted infectious virus and viral RNA transcripts in vaccinated animals upon MERS-CoV challenge.
http://www.sciencemag.org/content/351/6268/77.full
An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels
- Bart L. Haagmans1,*,
- Judith M. A. van den Brand1,
- V. Stalin Raj1,
- Asisa Volz2,
- Peter Wohlsein3,
- Saskia L. Smits1,
- Debby Schipper1,
- Theo M. Bestebroer1,
- Nisreen Okba1,
- Robert Fux2,
- Albert Bensaid4,
- David Solanes Foz4,
- Thijs Kuiken1,
- Wolfgang Baumg?rtner3,
- Joaquim Segal?s5,6,
- Gerd Sutter2,*,
- Albert D. M. E. Osterhaus1,7,8,*
Middle East respiratory syndrome coronavirus (MERS-CoV) infections have led to an ongoing outbreak in humans, which was fueled by multiple zoonotic MERS-CoV introductions from dromedary camels. In addition to the implementation of hygiene measures to limit further camel-to-human and human-to-human transmissions, vaccine-mediated reduction of MERS-CoV spread from the animal reservoir may be envisaged. Here we show that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS-CoV spike protein confers mucosal immunity in dromedary camels.
Compared with results for control animals, we observed a significant reduction of excreted infectious virus and viral RNA transcripts in vaccinated animals upon MERS-CoV challenge.
http://www.sciencemag.org/content/351/6268/77.full
Last edited: