tetano
Editor, Senior Moderator
Arch Virol. 2017 Oct 27. doi: 10.1007/s00705-017-3578-8. [Epub ahead of print]
[h=1]An influenza A virus vaccine based on an M2e-modified alphavirus.[/h] Krishnavajhala HR[SUP]1[/SUP], Williams J[SUP]1[/SUP], Heidner H[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The 23-residue external domain of the influenza A virus M2 protein (M2e) has significant potential as a vaccine antigen. Here, we describe the construction and characterization of an M2e-modified Sindbis virus designated E2S1-M2e. E2S1-M2e virions contain M2e as an N-terminal extension of the E2 glycoprotein and therefore express 240 copies of the M2e peptide on their surface. The E2S1-M2e virus expressed M2e in an accessible and immunogenic form and induced M2e-specific antibodies when administered to mice. Mice that received an intranasal vaccination with E2S1-M2e were protected against a lethal challenge with a virulent, mouse-adapted strain of influenza A virus.
PMID: 29079954 DOI: 10.1007/s00705-017-3578-8
[h=1]An influenza A virus vaccine based on an M2e-modified alphavirus.[/h] Krishnavajhala HR[SUP]1[/SUP], Williams J[SUP]1[/SUP], Heidner H[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The 23-residue external domain of the influenza A virus M2 protein (M2e) has significant potential as a vaccine antigen. Here, we describe the construction and characterization of an M2e-modified Sindbis virus designated E2S1-M2e. E2S1-M2e virions contain M2e as an N-terminal extension of the E2 glycoprotein and therefore express 240 copies of the M2e peptide on their surface. The E2S1-M2e virus expressed M2e in an accessible and immunogenic form and induced M2e-specific antibodies when administered to mice. Mice that received an intranasal vaccination with E2S1-M2e were protected against a lethal challenge with a virulent, mouse-adapted strain of influenza A virus.
PMID: 29079954 DOI: 10.1007/s00705-017-3578-8