tetano
Editor, Senior Moderator
J Immunol Res. 2018 Feb 25;2018:3174868. doi: 10.1155/2018/3174868. eCollection 2018.
[h=1]An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.[/h] Falf?n-Valencia R[SUP]1[/SUP], Narayanankutty A[SUP]1[/SUP], Res?ndiz-Hern?ndez JM[SUP]1[/SUP], P?rez-Rubio G[SUP]1[/SUP], Ram?rez-Venegas A[SUP]2[/SUP], Nava-Quiroz KJ[SUP]1[/SUP], Bautista-F?lix NE[SUP]2[/SUP], Vargas-Alarc?n G[SUP]3[/SUP], Castillejos-L?pez MDJ[SUP]4[/SUP], Hern?ndez A[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic.
[h=4]Methods:[/h] We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method.
[h=4]Results:[/h] Our analysis revealed higher frequency of C∗07:02:01, B∗39:06:02, C∗03:02:01, B∗44:03:01, B∗51:01:05, and B∗73:01 (p < 0.05; OR = 1.84-9.98) and of two haplotypes-A∗68:01:02-C∗07:02:01 (p = 1.05E - 05; OR = 23.99) and B∗35:01:01-C∗07:02.01 (p = 4.15E - 04, OR = 2.15)-in A H1N1/09 influenza subjects. A∗68:01:01 was exclusively present only in the INF-P group (5/138). A decrease in the frequency of C∗03:03:01, A∗11:01:01, B∗39:01:01, A∗24:02:01, C∗03:04:01, B∗51:01:01, and C∗07:01:01 (p < 0.05; OR = 0.12-0.52) and of haplotypes A∗02:01:01-B∗35:01:01-C∗04:01:01, A∗24:02:01-B∗35:01:01, B∗39:01:01-C∗07:02:01, and B∗40:02:01-C∗03:04:01 (p < 0.05; OR = 0.08-0.22) were observed in INF-P group.
[h=4]Conclusion:[/h] Selective classical HLA class I allele and haplotype combinations predispose individuals towards susceptibility or protection against the influenza A H1N1/09 pandemic. This work has significant implications for accessing population transmission risk for A H1N1/09 or a similar strain breakout in the future.
PMID: 29682588 PMCID: PMC5845504 DOI: 10.1155/2018/3174868
[h=1]An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.[/h] Falf?n-Valencia R[SUP]1[/SUP], Narayanankutty A[SUP]1[/SUP], Res?ndiz-Hern?ndez JM[SUP]1[/SUP], P?rez-Rubio G[SUP]1[/SUP], Ram?rez-Venegas A[SUP]2[/SUP], Nava-Quiroz KJ[SUP]1[/SUP], Bautista-F?lix NE[SUP]2[/SUP], Vargas-Alarc?n G[SUP]3[/SUP], Castillejos-L?pez MDJ[SUP]4[/SUP], Hern?ndez A[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic.
[h=4]Methods:[/h] We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method.
[h=4]Results:[/h] Our analysis revealed higher frequency of C∗07:02:01, B∗39:06:02, C∗03:02:01, B∗44:03:01, B∗51:01:05, and B∗73:01 (p < 0.05; OR = 1.84-9.98) and of two haplotypes-A∗68:01:02-C∗07:02:01 (p = 1.05E - 05; OR = 23.99) and B∗35:01:01-C∗07:02.01 (p = 4.15E - 04, OR = 2.15)-in A H1N1/09 influenza subjects. A∗68:01:01 was exclusively present only in the INF-P group (5/138). A decrease in the frequency of C∗03:03:01, A∗11:01:01, B∗39:01:01, A∗24:02:01, C∗03:04:01, B∗51:01:01, and C∗07:01:01 (p < 0.05; OR = 0.12-0.52) and of haplotypes A∗02:01:01-B∗35:01:01-C∗04:01:01, A∗24:02:01-B∗35:01:01, B∗39:01:01-C∗07:02:01, and B∗40:02:01-C∗03:04:01 (p < 0.05; OR = 0.08-0.22) were observed in INF-P group.
[h=4]Conclusion:[/h] Selective classical HLA class I allele and haplotype combinations predispose individuals towards susceptibility or protection against the influenza A H1N1/09 pandemic. This work has significant implications for accessing population transmission risk for A H1N1/09 or a similar strain breakout in the future.
PMID: 29682588 PMCID: PMC5845504 DOI: 10.1155/2018/3174868