An emerging avian influenza A virus H5N7 is a genetic reassortant of highly pathogeni

[Mingus]

http://www.ncbi.nlm.nih.gov/entrez/..._uids=16814904&query_hl=4&itool=pubmed_docsum

1: Vaccine. 2006 Jun 6; [Epub ahead of print] Related Articles, Links
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An emerging avian influenza A virus H5N7 is a genetic reassortant of highly pathogenic genes.

Bragstad K, Jorgensen PH, Handberg KJ, Fomsgaard A.

Department of Virology, Statens Serum Institut, 5 Artillerivej, DK-2300 Copenhagen S, Denmark.

We full genome characterised the newly discovered avian influenza virus H5N7 subtype combination isolated from a stock of Danish game ducks to investigate the composition of the genome and possible features of high pathogenicity. It was found that the haemagglutinin and the acidic polymerase genes were closely related to a low pathogenic H5 strain (A/Duck/Denmark/65047/04 H5N2). The neuraminidase and the non-structural genes were closely related to the highly pathogenic H7N7 strains from The Netherlands 2003. The basic polymerase genes 1 and 2 were shared between the Danish H5N7 and H5N2 and the H7N7 from The Netherlands. The nucleoprotein and the matrix genes were closely related to H6 strains. Thus, the new H5N7 subtype share genes with H5, H7 and H6 subtypes and possesses internal genes originating from highly pathogenic strains. The findings emphasize the need for surveillance presumed low pathogenic avian influenza A viruses.

PMID: 16814904 [PubMed - as supplied by publisher]

 

[Mellie]

Re: An emerging avian influenza A virus H5N7 is a genetic reassortant of highly patho

Re: An emerging avian influenza A virus H5N7 is a genetic reassortant of highly patho

Hmmm, I guess this another why there's culling going on in Denmark... if I'm reading things correctly???

http://www.flutrackers.com/forum/showthread.php?t=7794
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[Snowy Owl]

Re: An emerging avian influenza A virus H5N7 is a genetic reassortant of highly patho

Re: An emerging avian influenza A virus H5N7 is a genetic reassortant of highly patho

Doctor Niman,

Can you please share your reading of this ??

Thank you,

SO

 

[HenryN]

Re: An emerging avian influenza A virus H5N7 is a genetic reassortant of highly patho

Re: An emerging avian influenza A virus H5N7 is a genetic reassortant of highly patho

Doctor Niman,

Can you please share your reading of this ??

Thank you,

SO

I would guess this story is about a 2003 H5N7 isolate

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&query_hl=1&list_uids=15763149

 

[Mellie]

Re: An emerging avian influenza A virus H5N7 is a genetic reassortant of highly patho

Re: An emerging avian influenza A virus H5N7 is a genetic reassortant of highly patho

Virus Res. 2005 May;109(2):181-90.

[SIZE=+1]New avian influenza A virus subtype combination H5N7 identified in Danish mallard ducks.[/SIZE]

Bragstad K, Jorgensen PH, Handberg KJ, Mellergaard S, Corbet S, Fomsgaard A.

Department of Virology, Statens Serum Institut, 5 Artillerivej, DK-2300 Copenhagen S, Denmark.

During the past years increasing incidences of influenza A zoonosis have made it of uppermost importance to possess methods for rapid and precise identification and characterisation of influenza A viruses. We present here a convenient one-step RT-PCR method that will amplify full-length haemagglutinin (HA) and neuraminidase (NA) directly from clinical samples and from all known subtypes of influenza A. We applied the method on samples collected in September 2003 from a Danish flock of mallards with general health problems and by this a previously undescribed influenza A subtype combination, H5N7, was identified. The HA gene showed great sequence similarity to the highly pathogenic avian influenza A virus (HPAIV) A/Chicken/Italy/312/97 (H5N2); however, the cleavage site sequence between HA1 and HA2 had a motif typical for low pathogenic avian influenza viruses (LPAIV). The full-length NA sequence was most closely related to the HPAIV A/Chicken/Netherlands/01/03 (H7N7) that infected chickens and humans in the Netherlands in 2003. Ten persons with direct or indirect contact with the Danish mallard ducks showed signs of influenza-like illness 2-3 days following the killing of the ducks, but no evidence of influence infections was detected. To our knowledge this is the first report of an H5N7 influenza A virus.

PMID: 15763149 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&query_hl=1&list_uids=15763149
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