tetano
Editor, Senior Moderator
PLoS One. 2015 Oct 29;10(10):e0141312. doi: 10.1371/journal.pone.0141312. eCollection 2015.
[h=1]An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein.[/h] Yoon A[SUP]1[/SUP], Yi KS[SUP]2[/SUP], Chang SY[SUP]3[/SUP], Kim SH[SUP]2[/SUP], Song M[SUP]4[/SUP], Choi JA[SUP]4[/SUP], Bourgeois M[SUP]5[/SUP], Hossain MJ[SUP]5[/SUP], Chen LM[SUP]5[/SUP], Donis RO[SUP]5[/SUP], Kim H[SUP]1[/SUP], Lee Y[SUP]1[/SUP], Hwang do B[SUP]1[/SUP], Min JY[SUP]3[/SUP], Chang SJ[SUP]2[/SUP], Chung J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] To date, four main mechanisms mediating inhibition of influenza infection by anti-hemagglutinin antibodies have been reported. Anti-globular-head-domain antibodies block either influenza virus receptor binding to the host cell or progeny virion release from the host cell. Anti-stem region antibodies hinder the membrane fusion process or induce antibody-dependent cytotoxicity to infected cells. In this study we identified a human monoclonal IgG1 antibody (CT302), which does not inhibit both the receptor binding and the membrane fusion process but efficiently reduced the nucleus entry of viral nucleoprotein suggesting a novel inhibition mechanism of viral infection by antibody. This antibody binds to the subtype-H3 hemagglutinin globular head domain of group-2 influenza viruses circulating throughout the population between 1997 and 2007.
PMID: 26512723 [PubMed - in process]
[h=1]An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein.[/h] Yoon A[SUP]1[/SUP], Yi KS[SUP]2[/SUP], Chang SY[SUP]3[/SUP], Kim SH[SUP]2[/SUP], Song M[SUP]4[/SUP], Choi JA[SUP]4[/SUP], Bourgeois M[SUP]5[/SUP], Hossain MJ[SUP]5[/SUP], Chen LM[SUP]5[/SUP], Donis RO[SUP]5[/SUP], Kim H[SUP]1[/SUP], Lee Y[SUP]1[/SUP], Hwang do B[SUP]1[/SUP], Min JY[SUP]3[/SUP], Chang SJ[SUP]2[/SUP], Chung J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] To date, four main mechanisms mediating inhibition of influenza infection by anti-hemagglutinin antibodies have been reported. Anti-globular-head-domain antibodies block either influenza virus receptor binding to the host cell or progeny virion release from the host cell. Anti-stem region antibodies hinder the membrane fusion process or induce antibody-dependent cytotoxicity to infected cells. In this study we identified a human monoclonal IgG1 antibody (CT302), which does not inhibit both the receptor binding and the membrane fusion process but efficiently reduced the nucleus entry of viral nucleoprotein suggesting a novel inhibition mechanism of viral infection by antibody. This antibody binds to the subtype-H3 hemagglutinin globular head domain of group-2 influenza viruses circulating throughout the population between 1997 and 2007.
PMID: 26512723 [PubMed - in process]