tetano
Editor, Senior Moderator
Clin Immunol. 2013 Mar 15;147(2):79-88. doi: 10.1016/j.clim.2013.02.022. [Epub ahead of print]
An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans.
Kang KS, Lee N, Shin MS, Kim SD, Yu Y, Mohanty S, Belshe RB, Montgomery RR, Shaw AC, Kang I.
Source
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA; Department of Pediatrics, Jeju National University School of Medicine, Jeju, 690-756, Republic of Korea.
Abstract
Alterations in T cell immunity occur with aging. Influenza causes significant morbidity and mortality in the elderly. We investigated the relationship of serum IgG responses with hemagglutinin inhibition (HI) antibody titers and the frequency of distinct T cell subsets in young and elderly people who received the inactivated influenza vaccine. Influenza vaccine-specific IgG responses correlated with the increase of HI antibody titers and the frequency of CD4+ T cells producing IFN-γ and IL-17 in young, but not elderly, people. Also, only in young people, such IgG responses correlated with the frequency of memory T cells, especially central memory cells, CD45RA- effector memory CD8+ T cells and IL-7 receptor alpha high effector memory CD8+ T cells with potent survival and proliferative capacity. These findings suggest that aging alters the association of influenza-vaccine specific IgG responses with HI antibody titers, cytokine-producing capacity and proportions of memory T cells in humans.
Copyright ? 2013 Elsevier Inc. All rights reserved.
PMID:
23578549
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23578549
An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans.
Kang KS, Lee N, Shin MS, Kim SD, Yu Y, Mohanty S, Belshe RB, Montgomery RR, Shaw AC, Kang I.
Source
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA; Department of Pediatrics, Jeju National University School of Medicine, Jeju, 690-756, Republic of Korea.
Abstract
Alterations in T cell immunity occur with aging. Influenza causes significant morbidity and mortality in the elderly. We investigated the relationship of serum IgG responses with hemagglutinin inhibition (HI) antibody titers and the frequency of distinct T cell subsets in young and elderly people who received the inactivated influenza vaccine. Influenza vaccine-specific IgG responses correlated with the increase of HI antibody titers and the frequency of CD4+ T cells producing IFN-γ and IL-17 in young, but not elderly, people. Also, only in young people, such IgG responses correlated with the frequency of memory T cells, especially central memory cells, CD45RA- effector memory CD8+ T cells and IL-7 receptor alpha high effector memory CD8+ T cells with potent survival and proliferative capacity. These findings suggest that aging alters the association of influenza-vaccine specific IgG responses with HI antibody titers, cytokine-producing capacity and proportions of memory T cells in humans.
Copyright ? 2013 Elsevier Inc. All rights reserved.
PMID:
23578549
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23578549