tetano
Editor, Senior Moderator
An Agent-Based Model to study the epidemiological and evolutionary dynamics of Influenza viruses
Benjamin Roche email, John M Drake email and Pejman Rohani email
BMC Bioinformatics 2011, 12:87doi:10.1186/1471-2105-12-87
Published: 30 March 2011
Abstract (provisional)
Background
Influenza A viruses exhibit complex epidemiological patterns in a number of mammalian and avian hosts. Understanding transmission of these viruses necessitates taking into account their evolution, which represents a challenge for developing mathematical models. This is because the phrasing of multi-strain systems in terms of traditional compartmental ODE models either requires simplifying assumptions to be made that overlook important evolutionary processes, or leads to complex dynamical systems that are too cumbersome to analyse.
Results
Here, we develop an Individual-Based Model (IBM) in order to address simultaneously the ecology, epidemiology and evolution of strain-polymorphic pathogens, using Influenza A viruses as an illustrative example.
Conclusions
We carry out careful validation of our IBM against comparable mathematical models to demonstrate the robustness of our algorithm and the sound basis for this novel framework. We discuss how this new approach can give critical insights in the study of influenza evolution.
http://www.biomedcentral.com/content/pdf/1471-2105-12-87.pdf
Benjamin Roche email, John M Drake email and Pejman Rohani email
BMC Bioinformatics 2011, 12:87doi:10.1186/1471-2105-12-87
Published: 30 March 2011
Abstract (provisional)
Background
Influenza A viruses exhibit complex epidemiological patterns in a number of mammalian and avian hosts. Understanding transmission of these viruses necessitates taking into account their evolution, which represents a challenge for developing mathematical models. This is because the phrasing of multi-strain systems in terms of traditional compartmental ODE models either requires simplifying assumptions to be made that overlook important evolutionary processes, or leads to complex dynamical systems that are too cumbersome to analyse.
Results
Here, we develop an Individual-Based Model (IBM) in order to address simultaneously the ecology, epidemiology and evolution of strain-polymorphic pathogens, using Influenza A viruses as an illustrative example.
Conclusions
We carry out careful validation of our IBM against comparable mathematical models to demonstrate the robustness of our algorithm and the sound basis for this novel framework. We discuss how this new approach can give critical insights in the study of influenza evolution.
http://www.biomedcentral.com/content/pdf/1471-2105-12-87.pdf