tetano
Editor, Senior Moderator
J Virol. 2012 Dec 26. [Epub ahead of print]
Amino acid 316 of hemagglutinin and the neuraminidase stalk length influence virulence of H9N2 influenza virus in chickens and mice.
Sun Y, Tan Y, Wei K, Sun H, Shi Y, Pu J, Yang H, Gao GF, Yin Y, Feng W, Perez DR, Liu J.
Source
Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Abstract
H9N2 influenza viruses with an A316S substitution in hemagglutinin (HA) and a shorter neuraminidase (NA) stalk have become predominant in China. The A316S was shown to increase HA cleavage efficiency when combining with short stalk NA, and the short stalk NA improved NA enzyme activity and release of virus from erythrocytes. Single or combination of these mutations strengthened the virulence of H9N2 virus in chickens and mice.
PMID:
23269805
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23269805
Amino acid 316 of hemagglutinin and the neuraminidase stalk length influence virulence of H9N2 influenza virus in chickens and mice.
Sun Y, Tan Y, Wei K, Sun H, Shi Y, Pu J, Yang H, Gao GF, Yin Y, Feng W, Perez DR, Liu J.
Source
Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Abstract
H9N2 influenza viruses with an A316S substitution in hemagglutinin (HA) and a shorter neuraminidase (NA) stalk have become predominant in China. The A316S was shown to increase HA cleavage efficiency when combining with short stalk NA, and the short stalk NA improved NA enzyme activity and release of virus from erythrocytes. Single or combination of these mutations strengthened the virulence of H9N2 virus in chickens and mice.
PMID:
23269805
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23269805