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Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China.

A

Anne

Senior Moderator
<dl class="PubmedArticle"><dt class="head">anne :

</dt><dt class="head">why did they give amantadine to poultry ?
</dt><dt class="head">
</dt><dt class="head">

</dt><dt class="head">Antiviral Res. 2008 Jan;77(1):72-6. Epub 2007 Sep 12.
</dt><dt class="head">
</dt><dt class="head">
</dt><dt class="head">
</dt><dt class="head"> <script language="JavaScript1.2"><!-- var Menu17897729 = [ ["UseLocalConfig", "jsmenu3Config", "", ""], ["CoreNucleotide" , "window.top.location='/sites/entrez?Db=nuccore&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_nuccore&LinkReadableName=CoreNucleotide&IdsFromResult=17897729&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Taxonomy via GenBank" , "window.top.location='/sites/entrez?Db=taxonomy&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_taxonomy_entrez&LinkReadableName=Taxonomy%20via%20GenBank&IdsFromResult=17897729&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Nucleotide" , "window.top.location='/sites/entrez?Db=nucleotide&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_nucleotide&LinkReadableName=Nucleotide&IdsFromResult=17897729&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Protein" , "window.top.location='/sites/entrez?Db=protein&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_protein&LinkReadableName=Protein&IdsFromResult=17897729&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""], ["LinkOut", "window.top.location='/sites/entrez?Cmd=ShowLinkOut&Db=pubmed&TermToSearch=17897729&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""] ] --></script>Links
</dt><dd class="abstract">Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China.

<!--AuthorList-->He G, Qiao J, Dong C, He C, Zhao L, Tian Y.
Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, People's Republic of China.
We tested the amantadine-resistance among avian influenza A (H5N1) viruses isolated from chicken in Hebei Province of Northern China from 2001 to 2005, and investigated the amantadine use in this area. Plague reduction assay in MDCK cells showed that 83.3% isolates (5/6) were amantadine-resistant strains. The M2 sequence analysis revealed that four of five resistant isolates contained the point mutations (Ser to Asn) at position 31 that could confer resistance to amantadine. These results indicated that the incidence of amantadine-resistant viruses isolated in Northern China was particularly high. In the investigation of amantadine use, we found that amantadine was used extensively in poultry farms in this area, which maybe was one of reasons of the high amantadine-resistance incidence.
PMID: 17897729 [PubMed - in process]
</dd></dl>
 
Re: Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern Chi

Re: Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern Chi

Anne said:
<DL class=PubmedArticle><DT class=head>anne :


<DT class=head>why did they give amantadine to poultry ?

<DT class=head>

<DT class=head>


<DT class=head>Antiviral Res. 2008 Jan;77(1):72-6. Epub 2007 Sep 12.

<DT class=head>

<DT class=head>

<DT class=head>

<DT class=head><SCRIPT language=JavaScript1.2><!-- var Menu17897729 = [ ["UseLocalConfig", "jsmenu3Config", "", ""], ["CoreNucleotide" , "window.top.location='/sites/entrez?Db=nuccore&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_nuccore&LinkReadableName=CoreNucleotide&IdsFromResult=17897729&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Taxonomy via GenBank" , "window.top.location='/sites/entrez?Db=taxonomy&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_taxonomy_entrez&LinkReadableName=Taxonomy%20via%20GenBank&IdsFromResult=17897729&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Nucleotide" , "window.top.location='/sites/entrez?Db=nucleotide&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_nucleotide&LinkReadableName=Nucleotide&IdsFromResult=17897729&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Protein" , "window.top.location='/sites/entrez?Db=protein&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_protein&LinkReadableName=Protein&IdsFromResult=17897729&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""], ["LinkOut", "window.top.location='/sites/entrez?Cmd=ShowLinkOut&Db=pubmed&TermToSearch=17897729&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus' ", "", ""] ] --></SCRIPT>Links

<DD class=abstract>Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China.

<!--AuthorList-->He G, Qiao J, Dong C, He C, Zhao L, Tian Y.
Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, People's Republic of China.
We tested the amantadine-resistance among avian influenza A (H5N1) viruses isolated from chicken in Hebei Province of Northern China from 2001 to 2005, and investigated the amantadine use in this area. Plague reduction assay in MDCK cells showed that 83.3% isolates (5/6) were amantadine-resistant strains. The M2 sequence analysis revealed that four of five resistant isolates contained the point mutations (Ser to Asn) at position 31 that could confer resistance to amantadine. These results indicated that the incidence of amantadine-resistant viruses isolated in Northern China was particularly high. In the investigation of amantadine use, we found that amantadine was used extensively in poultry farms in this area, which maybe was one of reasons of the high amantadine-resistance incidence.
PMID: 17897729 [PubMed - in process]

</DD></DL>
Click to expand...
Bird flu
 
Re: Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern Chi

Re: Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern Chi

I thought that the predominant circulating strain had lost its Amandtadine resistance, supplanting the viral type that was. Additionally, I had thought that they had stopped giving it to poultry in the meantime, to prevent this occurring again. If this is the case why should it re-establish itself now? Or am I mistaken?
 
Re: Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern Chi

Re: Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern Chi

<DT class=head>"anne : </DT>




<DT class=head>why did they give amantadine to poultry ?"<DT class=head> <DT class=head><DT class=head><DT class=head>I think the reason is only economical for the big, or a matter of try to survive for the small farmers.<DT class=head> <DT class=head><DT class=head><DT class=head>The "big cages" do not want, and the small farmers cannot afford loosing poultry because of illnesses, and then they fill them with everything they think will stop the progression of the illness (or even preventively) before they place them to the market.


<DT class=head>We all now that everywhere the animals are pumped with all kind of hormones, antibiotics, vaccines,..., for the same reason.<DT class=head>No matter that this practice produced superbugs ... :yinyang:


</DT>
 
Re: Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern Chi

Re: Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern Chi

thanks.
I had never read it for poultry, but sometimes for rare birds in zoo..so I was very astonished.
 
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