tetano
Editor, Senior Moderator
Am Surg
. 2020 Dec 29;3134820983198.
doi: 10.1177/0003134820983198. Online ahead of print.
Extracorporeal Membrane Oxygenation for COVID-19-Associated Multisystem Inflammatory Syndrome in a 5-year-old
Stephanie P Schwartz[SUP] 1 [/SUP], Tracie C Walker[SUP] 1 [/SUP], Margaret Kihlstrom[SUP] 1 [/SUP], Mubina Isani[SUP] 2 [/SUP], Melissa M Smith[SUP] 1 [/SUP], Rebecca L Smith[SUP] 1 [/SUP], Sean E McLean[SUP] 2 [/SUP], Katherine C Clement[SUP] 1 [/SUP], Michael R Phillips[SUP] 2 [/SUP]
Affiliations
Abstract
Severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) is associated with multisystem inflammatory syndrome in children (MIS-C) that ranges from mild symptoms to cardiopulmonary collapse. A 5-year-old girl presented with shock and a rapid decline in left ventricular function requiring intubation. SARS-CoV-2 was diagnosed by viral Polymerase Chain Reaction (PCR), and she received remdesivir and COVID-19 convalescent plasma. Initial echocardiogram (ECHO) demonstrated low normal left ventricular function and mild left anterior descending coronary artery dilation. She remained hypotensive, despite high-dose epinephrine and norepinephrine infusions as well as stress-dose hydrocortisone. Admission SARS-CoV-2 IgG assay was positive, meeting the criteria for MIS-C. An ECHO 9 hours after admission demonstrated a severe decline in left ventricular function. Due to severe cardiogenic shock, she was cannulated for venoarterial extracorporeal support (ECMO). During her ECMO course, she was treated with remdesivir, intravenous methylprednisolone, intravenous immunoglobulin, and anakinra. She was decannulated on ECMO day 7, extubated the following day, and discharged home 2 weeks later without respiratory or cardiac support. The use of ECMO for cardiopulmonary support for pediatric patients with MIS-C is feasible and should be considered early as part of the treatment algorithm for patients with severe cardiopulmonary dysfunction.
Keywords: COVID-19; critical care; extracorporeal membrane oxygenation; multisystem inflammatory syndrome in children; pediatrics.
. 2020 Dec 29;3134820983198.
doi: 10.1177/0003134820983198. Online ahead of print.
Extracorporeal Membrane Oxygenation for COVID-19-Associated Multisystem Inflammatory Syndrome in a 5-year-old
Stephanie P Schwartz[SUP] 1 [/SUP], Tracie C Walker[SUP] 1 [/SUP], Margaret Kihlstrom[SUP] 1 [/SUP], Mubina Isani[SUP] 2 [/SUP], Melissa M Smith[SUP] 1 [/SUP], Rebecca L Smith[SUP] 1 [/SUP], Sean E McLean[SUP] 2 [/SUP], Katherine C Clement[SUP] 1 [/SUP], Michael R Phillips[SUP] 2 [/SUP]
Affiliations
- PMID: 33372818
- DOI: 10.1177/0003134820983198
Abstract
Severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) is associated with multisystem inflammatory syndrome in children (MIS-C) that ranges from mild symptoms to cardiopulmonary collapse. A 5-year-old girl presented with shock and a rapid decline in left ventricular function requiring intubation. SARS-CoV-2 was diagnosed by viral Polymerase Chain Reaction (PCR), and she received remdesivir and COVID-19 convalescent plasma. Initial echocardiogram (ECHO) demonstrated low normal left ventricular function and mild left anterior descending coronary artery dilation. She remained hypotensive, despite high-dose epinephrine and norepinephrine infusions as well as stress-dose hydrocortisone. Admission SARS-CoV-2 IgG assay was positive, meeting the criteria for MIS-C. An ECHO 9 hours after admission demonstrated a severe decline in left ventricular function. Due to severe cardiogenic shock, she was cannulated for venoarterial extracorporeal support (ECMO). During her ECMO course, she was treated with remdesivir, intravenous methylprednisolone, intravenous immunoglobulin, and anakinra. She was decannulated on ECMO day 7, extubated the following day, and discharged home 2 weeks later without respiratory or cardiac support. The use of ECMO for cardiopulmonary support for pediatric patients with MIS-C is feasible and should be considered early as part of the treatment algorithm for patients with severe cardiopulmonary dysfunction.
Keywords: COVID-19; critical care; extracorporeal membrane oxygenation; multisystem inflammatory syndrome in children; pediatrics.