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Am J Trop Med Hyg. Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel.

Giuseppe

Giuseppe

Emeritus
[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]


Am J Trop Med Hyg. 2013 Nov 25. [Epub ahead of print]

Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel.

Pichyangkul S, Krasaesub S, Jongkaewwattana A, Thitithanyanont A, Wiboon-Ut S, Yongvanitchit K, Limsalakpetch A, Kum-Arb U, Mongkolsirichaikul D, Khemnu N, Mahanonda R, Garcia JM, Mason CJ, Walsh DS, Saunders DL.

Source: Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; National Center for Genetic Engineering and Biotechnology, Pathum Thani, Thailand; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; Department of Dentistry, Chulalongkorn University, Bangkok, Thailand; Hong Kong University-Pasteur Research Center, Hong Kong.


Abstract

We studied cross-reactive antibodies against avian influenza H5N1 and 2009 pandemic (p) H1N1 in 200 serum samples from US military personnel collected before the H1N1 pandemic. Assays used to measure antibodies against viral proteins involved in protection included a hemagglutination inhibition (HI) assay and a neuraminidase inhibition (NI) assay. Viral neutralization by antibodies against avian influenza H5N1 and 2009 pH1N1 was assessed by influenza (H5) pseudotyped lentiviral particle-based and H1N1 microneutralization assays. Some US military personnel had cross-neutralizing antibodies against H5N1 (14%) and 2009 pH1N1 (16.5%). The odds of having cross-neutralizing antibodies against 2009 pH1N1 were 4.4 times higher in subjects receiving more than five inactivated whole influenza virus vaccinations than those subjects with no record of vaccination. Although unclear if the result of prior vaccination or disease exposure, these pre-existing antibodies may prevent or reduce disease severity.


PMID: 24277784 [PubMed - as supplied by publisher]


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Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel

Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel

Am J Trop Med Hyg. 2013 Nov 25. [Epub ahead of print]
Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel.
Pichyangkul S, Krasaesub S, Jongkaewwattana A, Thitithanyanont A, Wiboon-Ut S, Yongvanitchit K, Limsalakpetch A, Kum-Arb U, Mongkolsirichaikul D, Khemnu N, Mahanonda R, Garcia JM, Mason CJ, Walsh DS, Saunders DL.
Source

Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; National Center for Genetic Engineering and Biotechnology, Pathum Thani, Thailand; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; Department of Dentistry, Chulalongkorn University, Bangkok, Thailand; Hong Kong University-Pasteur Research Center, Hong Kong.
Abstract

We studied cross-reactive antibodies against avian influenza H5N1 and 2009 pandemic (p) H1N1 in 200 serum samples from US military personnel collected before the H1N1 pandemic. Assays used to measure antibodies against viral proteins involved in protection included a hemagglutination inhibition (HI) assay and a neuraminidase inhibition (NI) assay. Viral neutralization by antibodies against avian influenza H5N1 and 2009 pH1N1 was assessed by influenza (H5) pseudotyped lentiviral particle-based and H1N1 microneutralization assays. Some US military personnel had cross-neutralizing antibodies against H5N1 (14%) and 2009 pH1N1 (16.5%). The odds of having cross-neutralizing antibodies against 2009 pH1N1 were 4.4 times higher in subjects receiving more than five inactivated whole influenza virus vaccinations than those subjects with no record of vaccination. Although unclear if the result of prior vaccination or disease exposure, these pre-existing antibodies may prevent or reduce disease severity.

PMID:
24277784
[PubMed - as supplied by publisher]

Free full text

http://www.ncbi.nlm.nih.gov/pubmed/24277784
 
Re: Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel

Re: Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel

So doesn't this study imply that after 15ish years of circulating, many people have been exposed to H5N1?
 
Re: Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel

Re: Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel

I wonder what the H5N1 HI/MN cutoffs titres were used here?

Here is a list of other resources! (I'm sure you already have them on Flutrackers)

Wang et al. 2012 and Toner et al. 2012 meta-analysis gives good summaries and Wang provides HI/MN titre WHO cutoff criteria!
Van Kerkhove continues to push for universal protocols for sera-epi studes HI/MN cut off criteria!

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Sorry about the hyperlinks I need to update!
 
Re: Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel

Re: Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel

Short Report: Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel Am J Trop Med Hyg 13-0151; Published online November 25, 2013,
http://www.ajtmh.org/content/early/2013/11/21/ajtmh.13-0151.long

not open access article...:(
 
Re: Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel

Re: Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel

Another article of interest!

Bethell D, Saunders D, Jongkaewwattana A, Kramyu J, Thitithayanont A, et al. (2013) Evaluation of In Vitro Cross-Reactivity to Avian H5N1 and Pandemic H1N1 2009 Influenza Following Prime Boost Regimens of Seasonal Influenza Vaccination in Healthy Human Subjects: A Randomised Trial. PLoS ONE 8(3): e59674. doi:10.1371/journal.pone.0059674

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059674
 
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