tetano
Editor, Senior Moderator
Am J Trop Med Hyg
. 2024 Nov 12:tpmd230784.
doi: 10.4269/ajtmh.23-0784. Online ahead of print. Evidence of SARS-CoV-2 Spread in Rural Tanzania During the First 6 Months of the Global COVID-19 Pandemic
Srijana B Chhetri[SUP] 1 [/SUP], Daniel Nance[SUP] 1 [/SUP], Mwajabu Loya[SUP] 2 [/SUP], Caleb Cornaby[SUP] 3 [/SUP], Alena J Markmann[SUP] 1 [/SUP], John L Schmitz[SUP] 3 [/SUP], Jessica T Lin[SUP] 1 [/SUP], Billy Ngasala[SUP] 2 [/SUP]
Affiliations
In the first 6 months of the coronavirus disease 2019 pandemic, limited testing clouded understanding of the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in Africa. In particular, Tanzania halted all testing and reporting of SARS-CoV-2 cases after May 2020, not resuming until June 2021. In July-August 2020, we performed a seroprevalence survey in rural Bagamoyo district, 40 km outside Dar es Salaam. Among 347 asymptomatic children and adults, 64/347 (18.0%) demonstrated seroreactivity to SARS-CoV-2 spike receptor binding domain by ELISA. Given significant antibody cross-reactivity in malaria-endemic regions, seropositivity was additionally confirmed via a multitarget Luminex immunoassay. Thirty-seven, or 58% of initially seroreactive persons, were Luminex positive, leading to an estimated SARS-CoV-2 seroprevalence of 10.7% (37/347, 95% CI 7.6-14.4%). Working in health care appeared to be associated with seropositivity. Reporting of viral symptoms or health care-seeking behavior in the previous 3 months was not more frequent in seropositive individuals.
. 2024 Nov 12:tpmd230784.
doi: 10.4269/ajtmh.23-0784. Online ahead of print. Evidence of SARS-CoV-2 Spread in Rural Tanzania During the First 6 Months of the Global COVID-19 Pandemic
Srijana B Chhetri[SUP] 1 [/SUP], Daniel Nance[SUP] 1 [/SUP], Mwajabu Loya[SUP] 2 [/SUP], Caleb Cornaby[SUP] 3 [/SUP], Alena J Markmann[SUP] 1 [/SUP], John L Schmitz[SUP] 3 [/SUP], Jessica T Lin[SUP] 1 [/SUP], Billy Ngasala[SUP] 2 [/SUP]
Affiliations
- PMID: 39531720
- DOI: 10.4269/ajtmh.23-0784
In the first 6 months of the coronavirus disease 2019 pandemic, limited testing clouded understanding of the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in Africa. In particular, Tanzania halted all testing and reporting of SARS-CoV-2 cases after May 2020, not resuming until June 2021. In July-August 2020, we performed a seroprevalence survey in rural Bagamoyo district, 40 km outside Dar es Salaam. Among 347 asymptomatic children and adults, 64/347 (18.0%) demonstrated seroreactivity to SARS-CoV-2 spike receptor binding domain by ELISA. Given significant antibody cross-reactivity in malaria-endemic regions, seropositivity was additionally confirmed via a multitarget Luminex immunoassay. Thirty-seven, or 58% of initially seroreactive persons, were Luminex positive, leading to an estimated SARS-CoV-2 seroprevalence of 10.7% (37/347, 95% CI 7.6-14.4%). Working in health care appeared to be associated with seropositivity. Reporting of viral symptoms or health care-seeking behavior in the previous 3 months was not more frequent in seropositive individuals.