tetano
Editor, Senior Moderator
Am J Transplant. 2020 Apr 3. doi: 10.1111/ajt.15903. [Epub ahead of print]
A familial cluster, including a kidney transplant recipient, of Coronavirus Disease 2019 (COVID-19) in Wuhan, China.
Chen S[SUP]1,[/SUP][SUP]2[/SUP], Yin Q[SUP]3[/SUP], Shi H[SUP]1,[/SUP][SUP]2[/SUP], Du D[SUP]1,[/SUP][SUP]2[/SUP], Chang S[SUP]1,[/SUP][SUP]2[/SUP], Ni L[SUP]4[/SUP], Qiu H[SUP]3[/SUP], Chen Z[SUP]1,[/SUP][SUP]2[/SUP], Zhang J[SUP]3[/SUP], Zhang W[SUP]1,[/SUP][SUP]2[/SUP].
Author information
Abstract
In December 2019, an outbreak of COVID-19 occurred in Wuhan, China, and spread to the whole of China and to multiple countries worldwide. Unlike SARS and MERS, where secondary transmission mostly occurred in hospital settings, COVID-19 transmission occurs in large numbers within families. Herein we report three cases of a familial cluster with one family member being a kidney transplant recipient. The initial clinical symptoms of COVID-19 in these three patients were the same, but their progression was different. Based on the severity of clinical symptoms, chest computer tomography findings and SARS-Cov-2 RNA test results, we admitted the husband to the respiratory intensive care unit (RICU) and used a treatment consisting of immunosuppressant reduction/cessation and low dose methylprednisolone-based therapy, and his wife to the respiratory isolation ward. In contrast, the son received in-home isolation and home-based care. All three family members made a full recovery.
This article is protected by copyright. All rights reserved.
KEYWORDS:
COVID-19; kidney; novel coronavirus; pneumonia; transplantation; treatment
PMID:32243690DOI:10.1111/ajt.15903
A familial cluster, including a kidney transplant recipient, of Coronavirus Disease 2019 (COVID-19) in Wuhan, China.
Chen S[SUP]1,[/SUP][SUP]2[/SUP], Yin Q[SUP]3[/SUP], Shi H[SUP]1,[/SUP][SUP]2[/SUP], Du D[SUP]1,[/SUP][SUP]2[/SUP], Chang S[SUP]1,[/SUP][SUP]2[/SUP], Ni L[SUP]4[/SUP], Qiu H[SUP]3[/SUP], Chen Z[SUP]1,[/SUP][SUP]2[/SUP], Zhang J[SUP]3[/SUP], Zhang W[SUP]1,[/SUP][SUP]2[/SUP].
Author information
Abstract
In December 2019, an outbreak of COVID-19 occurred in Wuhan, China, and spread to the whole of China and to multiple countries worldwide. Unlike SARS and MERS, where secondary transmission mostly occurred in hospital settings, COVID-19 transmission occurs in large numbers within families. Herein we report three cases of a familial cluster with one family member being a kidney transplant recipient. The initial clinical symptoms of COVID-19 in these three patients were the same, but their progression was different. Based on the severity of clinical symptoms, chest computer tomography findings and SARS-Cov-2 RNA test results, we admitted the husband to the respiratory intensive care unit (RICU) and used a treatment consisting of immunosuppressant reduction/cessation and low dose methylprednisolone-based therapy, and his wife to the respiratory isolation ward. In contrast, the son received in-home isolation and home-based care. All three family members made a full recovery.
This article is protected by copyright. All rights reserved.
KEYWORDS:
COVID-19; kidney; novel coronavirus; pneumonia; transplantation; treatment
PMID:32243690DOI:10.1111/ajt.15903