tetano
Editor, Senior Moderator
Am J Transl Res
. 2021 Jun 15;13(6):6191-6199.
eCollection 2021.
Factors affecting recurrent positive RT-PCR results in clinically cured COVID-19 patients: a multicenter study
You Zou[SUP] 1 [/SUP], Jia-Ni Zou[SUP] 2 [/SUP], Ya-Se Zhuang[SUP] 3 [/SUP], Bin-Ru Wang[SUP] 4 [/SUP], Liu Sun[SUP] 5 [/SUP], Shan Xu[SUP] 1 [/SUP], Sheng-Lan Li[SUP] 6 [/SUP], Li-Jun Shen[SUP] 1 [/SUP], Geng-Tian Liang[SUP] 4 [/SUP], Qing-Quan Hua[SUP] 1 7 [/SUP], Wen-Cai Huang[SUP] 2 [/SUP], Shi-Ming Chen[SUP] 1 7 [/SUP]
Affiliations
Abstract
The aim of this study was to evaluate factors affecting the recurrence of positive RT-PCR results. By performing a retrospective analysis, we evaluated the clinical data of recurrent positive coronavirus disease 2019 (COVID-19) patients in multiple medical institutions in Wuhan. We recruited COVID-19 patients who were hospitalized from January 1 to March 10, 2020, in three tertiary hospitals in Wuhan, met the discharge criteria and received at least one additional nucleic acid test before leaving the hospital. According to the RT-PCR results, patients were split into a recurrent positive group (RPos group) and a nonrecurrent positive group (non-RPos group). Clinical characteristics, therapeutic schedules and antibody titers were compared between the two groups. AI-assisted chest high-resolution computed tomography (HRCT) technology was applied to investigate pulmonary inflammatory exudation and compare the extent of lung areas with different densities. This study involved 122 COVID-19 patients. There were no significant differences in age, sex, preexisting diseases, clinical symptoms, clinical classification, course of disease, therapeutic schedules or serum-specific antibodies between the two groups. A higher proportion of patients who showed pulmonary inflammatory exudation on HRCT scans were recurrent positive at the time of discharge than other patients (81.6% vs 13.7%, P < 0.01). In addition, the degree of pulmonary fibrosis was higher in the RPos group than in the non-RPos group (P < 0.05). Subpleural exudation at the peripheral edge of the lung and extensive pulmonary fibrosis at the time of discharge represent risk factors for the recurrence of COVID-19.
Keywords: AI-assisted; COVID-19; CT; recurrent positive.
. 2021 Jun 15;13(6):6191-6199.
eCollection 2021.
Factors affecting recurrent positive RT-PCR results in clinically cured COVID-19 patients: a multicenter study
You Zou[SUP] 1 [/SUP], Jia-Ni Zou[SUP] 2 [/SUP], Ya-Se Zhuang[SUP] 3 [/SUP], Bin-Ru Wang[SUP] 4 [/SUP], Liu Sun[SUP] 5 [/SUP], Shan Xu[SUP] 1 [/SUP], Sheng-Lan Li[SUP] 6 [/SUP], Li-Jun Shen[SUP] 1 [/SUP], Geng-Tian Liang[SUP] 4 [/SUP], Qing-Quan Hua[SUP] 1 7 [/SUP], Wen-Cai Huang[SUP] 2 [/SUP], Shi-Ming Chen[SUP] 1 7 [/SUP]
Affiliations
- PMID: 34306358
- PMCID: PMC8290760
Abstract
The aim of this study was to evaluate factors affecting the recurrence of positive RT-PCR results. By performing a retrospective analysis, we evaluated the clinical data of recurrent positive coronavirus disease 2019 (COVID-19) patients in multiple medical institutions in Wuhan. We recruited COVID-19 patients who were hospitalized from January 1 to March 10, 2020, in three tertiary hospitals in Wuhan, met the discharge criteria and received at least one additional nucleic acid test before leaving the hospital. According to the RT-PCR results, patients were split into a recurrent positive group (RPos group) and a nonrecurrent positive group (non-RPos group). Clinical characteristics, therapeutic schedules and antibody titers were compared between the two groups. AI-assisted chest high-resolution computed tomography (HRCT) technology was applied to investigate pulmonary inflammatory exudation and compare the extent of lung areas with different densities. This study involved 122 COVID-19 patients. There were no significant differences in age, sex, preexisting diseases, clinical symptoms, clinical classification, course of disease, therapeutic schedules or serum-specific antibodies between the two groups. A higher proportion of patients who showed pulmonary inflammatory exudation on HRCT scans were recurrent positive at the time of discharge than other patients (81.6% vs 13.7%, P < 0.01). In addition, the degree of pulmonary fibrosis was higher in the RPos group than in the non-RPos group (P < 0.05). Subpleural exudation at the peripheral edge of the lung and extensive pulmonary fibrosis at the time of discharge represent risk factors for the recurrence of COVID-19.
Keywords: AI-assisted; COVID-19; CT; recurrent positive.