tetano
Editor, Senior Moderator
Am J Respir Cell Mol Biol
. 2020 Jul 1.
doi: 10.1165/rcmb.2020-0169TR. Online ahead of print.
Age-dependent Differences in T Cell Responses to Influenza A Virus
Andrew D Prigge[SUP] 1 2 [/SUP], Ruihua Ma[SUP] 3 [/SUP], Bria M Coates[SUP] 4 1 [/SUP], Benjamin D Singer[SUP] 5 6 [/SUP], Karen M Ridge[SUP] 3 6 [/SUP]
Affiliations
Abstract
Respiratory infections from influenza A virus cause substantial morbidity and mortality in children relative to adults. T cells play a critical role in the host response to influenza A virus by supporting the innate and humoral responses, mediating cytotoxic activity, and promoting recovery. There are age-dependent differences in the number, subsets, and localization of T cells, which impact the host response to pathogens. In this article, we first review how T cells recognize influenza A virus and examine differences in the resting T cell populations between juveniles and adults. Next, we describe how the juvenile CD4[SUP]+[/SUP], CD8[SUP]+[/SUP], and regulatory T cell responses compare to those in adults and discuss the potential physiologic and clinical consequences of the differences. Finally, we explore the roles of two unconventional T cell types in the juvenile response to influenza, natural killer T cells and gamma-delta T cells. A clear understanding of age-dependent differences in the T cell response is essential to developing therapies to prevent or reverse the deleterious effects of influenza A virus in children.
Keywords: Age-dependent; Influenza; Juvenile; T Cell; Viral pneumonia.
. 2020 Jul 1.
doi: 10.1165/rcmb.2020-0169TR. Online ahead of print.
Age-dependent Differences in T Cell Responses to Influenza A Virus
Andrew D Prigge[SUP] 1 2 [/SUP], Ruihua Ma[SUP] 3 [/SUP], Bria M Coates[SUP] 4 1 [/SUP], Benjamin D Singer[SUP] 5 6 [/SUP], Karen M Ridge[SUP] 3 6 [/SUP]
Affiliations
- PMID: 32609537
- DOI: 10.1165/rcmb.2020-0169TR
Abstract
Respiratory infections from influenza A virus cause substantial morbidity and mortality in children relative to adults. T cells play a critical role in the host response to influenza A virus by supporting the innate and humoral responses, mediating cytotoxic activity, and promoting recovery. There are age-dependent differences in the number, subsets, and localization of T cells, which impact the host response to pathogens. In this article, we first review how T cells recognize influenza A virus and examine differences in the resting T cell populations between juveniles and adults. Next, we describe how the juvenile CD4[SUP]+[/SUP], CD8[SUP]+[/SUP], and regulatory T cell responses compare to those in adults and discuss the potential physiologic and clinical consequences of the differences. Finally, we explore the roles of two unconventional T cell types in the juvenile response to influenza, natural killer T cells and gamma-delta T cells. A clear understanding of age-dependent differences in the T cell response is essential to developing therapies to prevent or reverse the deleterious effects of influenza A virus in children.
Keywords: Age-dependent; Influenza; Juvenile; T Cell; Viral pneumonia.