tetano
Editor, Senior Moderator
Am J Public Health
. 2022 Nov 10;e1-e10.
doi: 10.2105/AJPH.2022.307108. Online ahead of print.
Timing and Trends for Municipal Wastewater, Lab-Confirmed Case, and Syndromic Case Surveillance of COVID-19 in Raleigh, North Carolina
Nadine Kotlarz[SUP] 1 [/SUP], David A Holcomb[SUP] 1 [/SUP], A B M Tanvir Pasha[SUP] 1 [/SUP], Stacie Reckling[SUP] 1 [/SUP], Judith Kays[SUP] 1 [/SUP], Yi-Chun Lai[SUP] 1 [/SUP], Sean Daly[SUP] 1 [/SUP], Sivaranjani Palani[SUP] 1 [/SUP], Erika Bailey[SUP] 1 [/SUP], Virginia T Guidry[SUP] 1 [/SUP], Ariel Christensen[SUP] 1 [/SUP], Steven Berkowitz[SUP] 1 [/SUP], Jane A Hoppin[SUP] 1 [/SUP], Helena Mitasova[SUP] 1 [/SUP], Lawrence S Engel[SUP] 1 [/SUP], Francis L de Los Reyes 3rd[SUP] 1 [/SUP], Angela Harris[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives. To compare 4 COVID-19 surveillance metrics in a major metropolitan area. Methods. We analyzed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in wastewater influent and primary solids in Raleigh, North Carolina, from April 10 through December 13, 2020. We compared wastewater results with lab-confirmed COVID-19 cases and syndromic COVID-like illness (CLI) cases to answer 3 questions: (1) Did they correlate? (2) What was the temporal alignment of the different surveillance systems? (3) Did periods of significant change (i.e., trends) align? Results. In the Raleigh sewershed, wastewater influent, wastewater primary solids, lab-confirmed cases, and CLI were strongly or moderately correlated. Trends in lab-confirmed cases and wastewater influent were observed earlier, followed by CLI and, lastly, wastewater primary solids. All 4 metrics showed sustained increases in COVID-19 in June, July, and November 2020 and sustained decreases in August and September 2020. Conclusions. In a major metropolitan area in 2020, the timing of and trends in municipal wastewater, lab-confirmed case, and syndromic case surveillance of COVID-19 were in general agreement. Public Health Implications. Our results provide evidence for investment in SARS-CoV-2 wastewater and CLI surveillance to complement information provided through lab-confirmed cases. (Am J Public Health. Published online ahead of print November 10, 2022:e1-e11. https://doi.org/10.2105/AJPH.2022.307108).
. 2022 Nov 10;e1-e10.
doi: 10.2105/AJPH.2022.307108. Online ahead of print.
Timing and Trends for Municipal Wastewater, Lab-Confirmed Case, and Syndromic Case Surveillance of COVID-19 in Raleigh, North Carolina
Nadine Kotlarz[SUP] 1 [/SUP], David A Holcomb[SUP] 1 [/SUP], A B M Tanvir Pasha[SUP] 1 [/SUP], Stacie Reckling[SUP] 1 [/SUP], Judith Kays[SUP] 1 [/SUP], Yi-Chun Lai[SUP] 1 [/SUP], Sean Daly[SUP] 1 [/SUP], Sivaranjani Palani[SUP] 1 [/SUP], Erika Bailey[SUP] 1 [/SUP], Virginia T Guidry[SUP] 1 [/SUP], Ariel Christensen[SUP] 1 [/SUP], Steven Berkowitz[SUP] 1 [/SUP], Jane A Hoppin[SUP] 1 [/SUP], Helena Mitasova[SUP] 1 [/SUP], Lawrence S Engel[SUP] 1 [/SUP], Francis L de Los Reyes 3rd[SUP] 1 [/SUP], Angela Harris[SUP] 1 [/SUP]
Affiliations
- PMID: 36356280
- DOI: 10.2105/AJPH.2022.307108
Abstract
Objectives. To compare 4 COVID-19 surveillance metrics in a major metropolitan area. Methods. We analyzed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in wastewater influent and primary solids in Raleigh, North Carolina, from April 10 through December 13, 2020. We compared wastewater results with lab-confirmed COVID-19 cases and syndromic COVID-like illness (CLI) cases to answer 3 questions: (1) Did they correlate? (2) What was the temporal alignment of the different surveillance systems? (3) Did periods of significant change (i.e., trends) align? Results. In the Raleigh sewershed, wastewater influent, wastewater primary solids, lab-confirmed cases, and CLI were strongly or moderately correlated. Trends in lab-confirmed cases and wastewater influent were observed earlier, followed by CLI and, lastly, wastewater primary solids. All 4 metrics showed sustained increases in COVID-19 in June, July, and November 2020 and sustained decreases in August and September 2020. Conclusions. In a major metropolitan area in 2020, the timing of and trends in municipal wastewater, lab-confirmed case, and syndromic case surveillance of COVID-19 were in general agreement. Public Health Implications. Our results provide evidence for investment in SARS-CoV-2 wastewater and CLI surveillance to complement information provided through lab-confirmed cases. (Am J Public Health. Published online ahead of print November 10, 2022:e1-e11. https://doi.org/10.2105/AJPH.2022.307108).