tetano
Editor, Senior Moderator
Am J Med Sci
. 2022 Feb 27;S0002-9629(22)00077-5.
doi: 10.1016/j.amjms.2022.02.005. Online ahead of print.
TEA Clinical Profile of Infective Endocarditis in Patients with Recent COVID-19: A Systematic Review
Juan A Quintero-Martinez[SUP] 1 [/SUP], Joya-Rita Hindy[SUP] 2 [/SUP], Maryam Mahmood[SUP] 2 [/SUP], Danielle J Gerberi[SUP] 3 [/SUP], Daniel C DeSimone[SUP] 2 [/SUP], Larry M Baddour[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) can progress to cardiovascular complications which are linked to higher in-hospital mortality rates. Infective endocarditis (IE) can develop in patients with recent COVID-19 infections, however, characterization of IE following COVID-19 infection has been lacking. To better characterize this disease, we performed a systematic review with descriptive analysis of the clinical features and outcomes of these patients.
Methods: Our search was conducted in 8 libraries for all published reports of probable or definite IE in patients with a prior COVID-19 confirmed diagnosis. After ensuring an appropriate inclusion of the articles, we extracted data related to clinical characteristics, modified duke criteria, microbiology, outcomes, and procedures.
Results: Searches generated a total of 323 published reports, and 20 articles met our inclusion criteria. The mean age of patients was 52.2 ± 16.9 years and 76.2% were males. Staphylococcus aureus was isolated in 8 (38.1%) patients, Enterococcus faecalis in 3 patients (14.3%) and Streptococcus mitis/oralis in 2 (9.5%) patients. The mean time interval between COVID-19 and IE diagnoses was 16.7 ± 15 days. Six (28.6%) patients required critical care due to IE, 7 patients (33.3%) underwent IE-related cardiac surgery and 5 patients (23.8%) died during their IE hospitalization.
Conclusions: Our systematic review provides a profile of clinical features and outcomes of patients with a prior COVID-19 infection diagnosis who subsequently developed IE. Due to the ongoing COVID-19 pandemic, it is essential that clinicians appreciate the possibility of IE as a unique complication of COVID-19 infection.
Keywords: COVID-19; Infective endocarditis; Outcomes; SARS-CoV-2.
. 2022 Feb 27;S0002-9629(22)00077-5.
doi: 10.1016/j.amjms.2022.02.005. Online ahead of print.
TEA Clinical Profile of Infective Endocarditis in Patients with Recent COVID-19: A Systematic Review
Juan A Quintero-Martinez[SUP] 1 [/SUP], Joya-Rita Hindy[SUP] 2 [/SUP], Maryam Mahmood[SUP] 2 [/SUP], Danielle J Gerberi[SUP] 3 [/SUP], Daniel C DeSimone[SUP] 2 [/SUP], Larry M Baddour[SUP] 2 [/SUP]
Affiliations
- PMID: 35235813
- DOI: 10.1016/j.amjms.2022.02.005
Abstract
Background: Coronavirus disease 2019 (COVID-19) can progress to cardiovascular complications which are linked to higher in-hospital mortality rates. Infective endocarditis (IE) can develop in patients with recent COVID-19 infections, however, characterization of IE following COVID-19 infection has been lacking. To better characterize this disease, we performed a systematic review with descriptive analysis of the clinical features and outcomes of these patients.
Methods: Our search was conducted in 8 libraries for all published reports of probable or definite IE in patients with a prior COVID-19 confirmed diagnosis. After ensuring an appropriate inclusion of the articles, we extracted data related to clinical characteristics, modified duke criteria, microbiology, outcomes, and procedures.
Results: Searches generated a total of 323 published reports, and 20 articles met our inclusion criteria. The mean age of patients was 52.2 ± 16.9 years and 76.2% were males. Staphylococcus aureus was isolated in 8 (38.1%) patients, Enterococcus faecalis in 3 patients (14.3%) and Streptococcus mitis/oralis in 2 (9.5%) patients. The mean time interval between COVID-19 and IE diagnoses was 16.7 ± 15 days. Six (28.6%) patients required critical care due to IE, 7 patients (33.3%) underwent IE-related cardiac surgery and 5 patients (23.8%) died during their IE hospitalization.
Conclusions: Our systematic review provides a profile of clinical features and outcomes of patients with a prior COVID-19 infection diagnosis who subsequently developed IE. Due to the ongoing COVID-19 pandemic, it is essential that clinicians appreciate the possibility of IE as a unique complication of COVID-19 infection.
Keywords: COVID-19; Infective endocarditis; Outcomes; SARS-CoV-2.