tetano
Editor, Senior Moderator
Am J Med
. 2023 Jan 16;S0002-9343(23)00016-5.
doi: 10.1016/j.amjmed.2022.12.029. Online ahead of print.
Physical Activity, Sedentary Behavior, and Risk of Coronavirus Disease 2019
Wenjie Ma[SUP] 1 [/SUP], Erin Murray[SUP] 2 [/SUP], Long H Nguyen[SUP] 1 [/SUP], David A Drew[SUP] 1 [/SUP], Ming Ding[SUP] 3 [/SUP], Konrad H Stopsack[SUP] 4 [/SUP], Janet W Rich-Edwards[SUP] 5 [/SUP], Jaime E Hart[SUP] 6 [/SUP], Jane C Figueiredo[SUP] 7 [/SUP], James V Lacey[SUP] 8 [/SUP], Alpa V Patel[SUP] 9 [/SUP], Shilpa N Bhupathiraju[SUP] 10 [/SUP], Andrew T Chan[SUP] 11 [/SUP], Maria Elena Martinez[SUP] 12 [/SUP]
Affiliations
Abstract
Introduction: Data on the associations of pre-pandemic physical activity and sedentary behavior with SARS-CoV-2 infection and Coronavirus Disease 2019 (COVID-19) severity, particularly milder illness, have been limited.
Methods: We used data from 43,913 participants within the Nurses' Health Study II and Health Professionals Follow-Up Study who responded to periodic COVID-related surveys from May 2020 through March 2021. History of physical activity from the pre-pandemic period was assessed as the metabolic equivalents of task (MET)-hours/week of various activities of different intensity and sedentary behavior assessed from reports of time spent sitting from questionnaires completed 2016-2017. Multivariable logistic regression models were fitted to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for risk of SARS-CoV-2 infection and COVID-19 severity, as well as predicted COVID-19 defined using a validated symptom-based algorithm.
Results: Higher levels of pre-pandemic physical activity were associated with a lower risk for SARS-CoV-2 infection. Compared to participants with <3 MET-hours/week, the multivariable-adjusted OR was 0.86 (95% CI:0.74, 0.99; P-trend=0.07) for those with ≥27 MET-hours/week. Higher physical activity levels were also associated with lower risk of symptomatic SARS-CoV-2 infection (OR:0.84; 95% CI:0.72, 0.99; P-trend=0.05) and predicted COVID-19 (OR:0.87; 95% CI:0.78, 0.97; P-trend=0.01). Longer time sitting at home watching TV (OR:0.85; 95% CI:0.73, 0.97) or for other tasks (OR:0.78; 95% CI:0.66, 0.92) was associated with a lower risk of SARS-CoV-2 infection.
Conclusions: Our findings support a protective association between pre-pandemic physical activity and lower risk and severity of COVID-19.
Keywords: COVID-19; Physical activity; SARS-CoV-2 infection; sedentary behavior.
. 2023 Jan 16;S0002-9343(23)00016-5.
doi: 10.1016/j.amjmed.2022.12.029. Online ahead of print.
Physical Activity, Sedentary Behavior, and Risk of Coronavirus Disease 2019
Wenjie Ma[SUP] 1 [/SUP], Erin Murray[SUP] 2 [/SUP], Long H Nguyen[SUP] 1 [/SUP], David A Drew[SUP] 1 [/SUP], Ming Ding[SUP] 3 [/SUP], Konrad H Stopsack[SUP] 4 [/SUP], Janet W Rich-Edwards[SUP] 5 [/SUP], Jaime E Hart[SUP] 6 [/SUP], Jane C Figueiredo[SUP] 7 [/SUP], James V Lacey[SUP] 8 [/SUP], Alpa V Patel[SUP] 9 [/SUP], Shilpa N Bhupathiraju[SUP] 10 [/SUP], Andrew T Chan[SUP] 11 [/SUP], Maria Elena Martinez[SUP] 12 [/SUP]
Affiliations
- PMID: 36657558
- DOI: 10.1016/j.amjmed.2022.12.029
Abstract
Introduction: Data on the associations of pre-pandemic physical activity and sedentary behavior with SARS-CoV-2 infection and Coronavirus Disease 2019 (COVID-19) severity, particularly milder illness, have been limited.
Methods: We used data from 43,913 participants within the Nurses' Health Study II and Health Professionals Follow-Up Study who responded to periodic COVID-related surveys from May 2020 through March 2021. History of physical activity from the pre-pandemic period was assessed as the metabolic equivalents of task (MET)-hours/week of various activities of different intensity and sedentary behavior assessed from reports of time spent sitting from questionnaires completed 2016-2017. Multivariable logistic regression models were fitted to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for risk of SARS-CoV-2 infection and COVID-19 severity, as well as predicted COVID-19 defined using a validated symptom-based algorithm.
Results: Higher levels of pre-pandemic physical activity were associated with a lower risk for SARS-CoV-2 infection. Compared to participants with <3 MET-hours/week, the multivariable-adjusted OR was 0.86 (95% CI:0.74, 0.99; P-trend=0.07) for those with ≥27 MET-hours/week. Higher physical activity levels were also associated with lower risk of symptomatic SARS-CoV-2 infection (OR:0.84; 95% CI:0.72, 0.99; P-trend=0.05) and predicted COVID-19 (OR:0.87; 95% CI:0.78, 0.97; P-trend=0.01). Longer time sitting at home watching TV (OR:0.85; 95% CI:0.73, 0.97) or for other tasks (OR:0.78; 95% CI:0.66, 0.92) was associated with a lower risk of SARS-CoV-2 infection.
Conclusions: Our findings support a protective association between pre-pandemic physical activity and lower risk and severity of COVID-19.
Keywords: COVID-19; Physical activity; SARS-CoV-2 infection; sedentary behavior.