tetano
Editor, Senior Moderator
Am J Med
. 2024 Feb 6:S0002-9343(24)00058-5.
doi: 10.1016/j.amjmed.2024.01.021. Online ahead of print. Factors associated with cognitive impairment in patients with persisting sequelae of Covid-19
Aaron Bonner-Jackson[SUP] 1 [/SUP], Rohun Vangal[SUP] 2 [/SUP], Yadi Li[SUP] 3 [/SUP], Nicolas Thompson[SUP] 3 [/SUP], Shinjon Chakrabarti[SUP] 4 [/SUP], Kamini Krishnan[SUP] 5 [/SUP]
Affiliations
Objective: Quantify cognitive deficits in patients with post-acute sequelae of Covid-19 (PASC) and identify key variables related to cognitive impairment in PASC.
Method: Patients with polymerase chain reaction (PCR) confirmed Covid-19 underwent a comprehensive neuropsychological evaluation. The comparison group included patients without neurological disorders determined to be cognitively intact by the neuropsychologist. Cognitive impairment was defined as impairment (Composite T ≤ 35) in one of six cognitive domains. The PASC group was split into impaired or intact based on the above criteria. Multivariable logistic regression models assessed predictors including demographics, Covid-19 severity, clinical characteristics, and mood.
Results: 210 patients with PASC were predominantly female (73.3%, p <0.001) without other demographic differences when compared to the 369 normal controls. Patients with PASC were more likely to have cognitive impairment (OR=3.61, 95% CI=2.36-5.54, p<0.001) compared to controls, with significantly lower scores in domains of memory, language, processing speed, visuospatial function, executive function (p<0.001) and higher depressive (p=.004) and anxiety symptoms (p=.003). Patients with PASC who demonstrated cognitive impairment (n=93) had higher body mass index compared to those with PASC without cognitive impairment (n=117), without differences in other predictors.
Conclusion: Patients with PASC are almost 4 times more likely to evidence cognitive dysfunction compared to normal controls. Forty-four percent of patients with PASC demonstrated cognitive deficits about 7 months from infection. Estimated premorbid intelligence significantly correlated with impairment. Higher Body Mass Index (BMI) was the only metric shown to differentiate those with PASC and cognitive impairment from those with PASC who were cognitively intact.
Keywords: Cognitive impairment; Coronavirus; Long-Covid-19 syndrome; Neuropsychological abnormalities; Post-Covid-19 syndrome; SARS-CoV-2.
. 2024 Feb 6:S0002-9343(24)00058-5.
doi: 10.1016/j.amjmed.2024.01.021. Online ahead of print. Factors associated with cognitive impairment in patients with persisting sequelae of Covid-19
Aaron Bonner-Jackson[SUP] 1 [/SUP], Rohun Vangal[SUP] 2 [/SUP], Yadi Li[SUP] 3 [/SUP], Nicolas Thompson[SUP] 3 [/SUP], Shinjon Chakrabarti[SUP] 4 [/SUP], Kamini Krishnan[SUP] 5 [/SUP]
Affiliations
- PMID: 38331138
- DOI: 10.1016/j.amjmed.2024.01.021
Objective: Quantify cognitive deficits in patients with post-acute sequelae of Covid-19 (PASC) and identify key variables related to cognitive impairment in PASC.
Method: Patients with polymerase chain reaction (PCR) confirmed Covid-19 underwent a comprehensive neuropsychological evaluation. The comparison group included patients without neurological disorders determined to be cognitively intact by the neuropsychologist. Cognitive impairment was defined as impairment (Composite T ≤ 35) in one of six cognitive domains. The PASC group was split into impaired or intact based on the above criteria. Multivariable logistic regression models assessed predictors including demographics, Covid-19 severity, clinical characteristics, and mood.
Results: 210 patients with PASC were predominantly female (73.3%, p <0.001) without other demographic differences when compared to the 369 normal controls. Patients with PASC were more likely to have cognitive impairment (OR=3.61, 95% CI=2.36-5.54, p<0.001) compared to controls, with significantly lower scores in domains of memory, language, processing speed, visuospatial function, executive function (p<0.001) and higher depressive (p=.004) and anxiety symptoms (p=.003). Patients with PASC who demonstrated cognitive impairment (n=93) had higher body mass index compared to those with PASC without cognitive impairment (n=117), without differences in other predictors.
Conclusion: Patients with PASC are almost 4 times more likely to evidence cognitive dysfunction compared to normal controls. Forty-four percent of patients with PASC demonstrated cognitive deficits about 7 months from infection. Estimated premorbid intelligence significantly correlated with impairment. Higher Body Mass Index (BMI) was the only metric shown to differentiate those with PASC and cognitive impairment from those with PASC who were cognitively intact.
Keywords: Cognitive impairment; Coronavirus; Long-Covid-19 syndrome; Neuropsychological abnormalities; Post-Covid-19 syndrome; SARS-CoV-2.
