tetano
Editor, Senior Moderator
Am J Med Case Rep
. 2020;8(7):192-196.
Epub 2020 Apr 22.
Pharmaco-invasive Therapy for STEMI in a Patient With COVID-19: A Case Report
Pramod Theetha Kariyanna[SUP] 1 [/SUP], Naseem Hossain[SUP] 1 [/SUP], Apoorva Jayarangaiah[SUP] 2 [/SUP], Nimrah A Hossain[SUP] 3 [/SUP], Jonathan Christopher Francois[SUP] 1 [/SUP], Jonathan D Marmur[SUP] 1 [/SUP], Moro O Salifu[SUP] 1 [/SUP], Samy I McFarlane[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a pandemic that started in the Wuhan province of China in December 2019. It is associated with increased morbidity and mortality mainly due to severe acute respiratory syndrome 2 (SARS-Cov-2). Cardiac manifestations related to COVID-19 include demand ischemia, fulminant myocarditis, myocardial infarction and arrhythmias. In this report, we present a case of ST-segment elevation myocardial infarction (STEMI) in a 68-year-old man with COVID-19 who initially presented with chest pain and shortness of breath. Patient's STEMI was managed with pharmaco-invasive strategy with tissue plasminogen activator (t-PA). He then developed acute hypoxic respiratory failure that was managed in the intensive care unit (ICU), together with multi-organ failure from which the patient died 2 days after presentation. Although the pathophysiologic mechanisms of STEMI in COVID-19 patients has not been clearly established, we hypothesize that interrelated pathogenetic factors, that we highlight in this report, can play a role in the development of STEMI, including plaque rupture secondary to systemic inflammation, increased pro-coagulants, endothelial dysfunction, impaired fibrinolysis and impaired oxygen utilization leading to demand/supply mismatch and myocardial ischemia.
Keywords: COVID-19; Pharmaco-invasive therapy; ST-segment elevation myocardial infarction (STEMI).
. 2020;8(7):192-196.
Epub 2020 Apr 22.
Pharmaco-invasive Therapy for STEMI in a Patient With COVID-19: A Case Report
Pramod Theetha Kariyanna[SUP] 1 [/SUP], Naseem Hossain[SUP] 1 [/SUP], Apoorva Jayarangaiah[SUP] 2 [/SUP], Nimrah A Hossain[SUP] 3 [/SUP], Jonathan Christopher Francois[SUP] 1 [/SUP], Jonathan D Marmur[SUP] 1 [/SUP], Moro O Salifu[SUP] 1 [/SUP], Samy I McFarlane[SUP] 1 [/SUP]
Affiliations
- PMID: 32432162
Abstract
Coronavirus disease 2019 (COVID-19) is a pandemic that started in the Wuhan province of China in December 2019. It is associated with increased morbidity and mortality mainly due to severe acute respiratory syndrome 2 (SARS-Cov-2). Cardiac manifestations related to COVID-19 include demand ischemia, fulminant myocarditis, myocardial infarction and arrhythmias. In this report, we present a case of ST-segment elevation myocardial infarction (STEMI) in a 68-year-old man with COVID-19 who initially presented with chest pain and shortness of breath. Patient's STEMI was managed with pharmaco-invasive strategy with tissue plasminogen activator (t-PA). He then developed acute hypoxic respiratory failure that was managed in the intensive care unit (ICU), together with multi-organ failure from which the patient died 2 days after presentation. Although the pathophysiologic mechanisms of STEMI in COVID-19 patients has not been clearly established, we hypothesize that interrelated pathogenetic factors, that we highlight in this report, can play a role in the development of STEMI, including plaque rupture secondary to systemic inflammation, increased pro-coagulants, endothelial dysfunction, impaired fibrinolysis and impaired oxygen utilization leading to demand/supply mismatch and myocardial ischemia.
Keywords: COVID-19; Pharmaco-invasive therapy; ST-segment elevation myocardial infarction (STEMI).