tetano
Editor, Senior Moderator
Am J Kidney Dis
. 2020 Oct 9;S0272-6386(20)31014-3.
doi: 10.1053/j.ajkd.2020.10.001. Online ahead of print.
Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria
Shreeram Akilesh[SUP] 1 [/SUP], Cynthia C Nast[SUP] 2 [/SUP], Michifumi Yamashita[SUP] 2 [/SUP], Kammi Henriksen[SUP] 3 [/SUP], Vivek Charu[SUP] 4 [/SUP], Megan L Troxell[SUP] 4 [/SUP], Neeraja Kambham[SUP] 4 [/SUP], Erika Bracamonte[SUP] 5 [/SUP], Donald Houghton[SUP] 6 [/SUP], Naila I Ahmed[SUP] 7 [/SUP], Chyi Chyi Chong[SUP] 8 [/SUP], Bijin Thajudeen[SUP] 8 [/SUP], Shehzad Rehman[SUP] 9 [/SUP], Firas Khoury[SUP] 10 [/SUP], Jonathan E Zuckerman[SUP] 11 [/SUP], Jeremy Gitomer[SUP] 12 [/SUP], Parthassarathy C Raguram[SUP] 13 [/SUP], Shanza Mujeeb[SUP] 13 [/SUP], Ulrike Schwarze[SUP] 14 [/SUP], M Brendan Shannon[SUP] 15 [/SUP], Iris De Castro[SUP] 15 [/SUP], Charles E Alpers[SUP] 14 [/SUP], Behzad Najafian[SUP] 14 [/SUP], Roberto F Nicosia[SUP] 14 [/SUP], Nicole K Andeen[SUP] 16 [/SUP], Kelly D Smith[SUP] 17 [/SUP]
Affiliations
Abstract
Rationale and objective: Kidney biopsy data inform us about pathologic processes associated with SARS CoV-2 infection. We conducted a multi-center evaluation of kidney biopsy findings in living patients to identify various kidney disease pathology in patients with COVID-19 and their association with SARS-CoV-2 infection.
Study design: Case series.
Setting and participants: We identified 14 native and 3 transplant kidney biopsies performed for-cause in patients with documented recent or concurrent COVID-19 infection treated at 7 large hospital systems in the United States.
Observations: Males and females were equally represented in our study cohort, with a higher proportion of Black (n=8) and Hispanic (n=5) patients. All 17 patients had RT-PCR confirmed COVID-19 infection, but only 3 presented with severe COVID-19 symptoms. Acute kidney injury (AKI; n=15) and proteinuria (n=11) were the most common indications for biopsy and these symptoms developed concurrently or within 1 week of COVID-19 symptoms in all patients. Acute tubular injury (n=14), collapsing glomerulopathy (n=7) and endothelial injury/thrombotic microangiopathy (n=6) were the most common histologic findings. Two of the three transplant patients developed active antibody-mediated rejection weeks after COVID-19 infection. Eight patients required dialysis, but others improved with conservative management.
Limitations: Small study size and short clinical follow up.
Conclusions: Cases of even symptomatically mild COVID-19 infection were accompanied by AKI and/or heavy proteinuria that prompted a diagnostic kidney biopsy. While acute tubular injury was seen among the majority of them, uncommon pathology such as collapsing glomerulopathy and acute endothelial injury were detected, and most of these patients progressed to irreversible kidney injury and dialysis.
Keywords: Coronavirus disease 2019 (COVID-19); acute kidney injury (AKI); allograft biopsy; antibody-mediated rejection; case series; collapsing glomerulopathy; kidney biopsy; renal complications of COVID-19; renal pathology; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); thrombotic microangiopathy.
. 2020 Oct 9;S0272-6386(20)31014-3.
doi: 10.1053/j.ajkd.2020.10.001. Online ahead of print.
Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria
Shreeram Akilesh[SUP] 1 [/SUP], Cynthia C Nast[SUP] 2 [/SUP], Michifumi Yamashita[SUP] 2 [/SUP], Kammi Henriksen[SUP] 3 [/SUP], Vivek Charu[SUP] 4 [/SUP], Megan L Troxell[SUP] 4 [/SUP], Neeraja Kambham[SUP] 4 [/SUP], Erika Bracamonte[SUP] 5 [/SUP], Donald Houghton[SUP] 6 [/SUP], Naila I Ahmed[SUP] 7 [/SUP], Chyi Chyi Chong[SUP] 8 [/SUP], Bijin Thajudeen[SUP] 8 [/SUP], Shehzad Rehman[SUP] 9 [/SUP], Firas Khoury[SUP] 10 [/SUP], Jonathan E Zuckerman[SUP] 11 [/SUP], Jeremy Gitomer[SUP] 12 [/SUP], Parthassarathy C Raguram[SUP] 13 [/SUP], Shanza Mujeeb[SUP] 13 [/SUP], Ulrike Schwarze[SUP] 14 [/SUP], M Brendan Shannon[SUP] 15 [/SUP], Iris De Castro[SUP] 15 [/SUP], Charles E Alpers[SUP] 14 [/SUP], Behzad Najafian[SUP] 14 [/SUP], Roberto F Nicosia[SUP] 14 [/SUP], Nicole K Andeen[SUP] 16 [/SUP], Kelly D Smith[SUP] 17 [/SUP]
Affiliations
- PMID: 33045255
- DOI: 10.1053/j.ajkd.2020.10.001
Abstract
Rationale and objective: Kidney biopsy data inform us about pathologic processes associated with SARS CoV-2 infection. We conducted a multi-center evaluation of kidney biopsy findings in living patients to identify various kidney disease pathology in patients with COVID-19 and their association with SARS-CoV-2 infection.
Study design: Case series.
Setting and participants: We identified 14 native and 3 transplant kidney biopsies performed for-cause in patients with documented recent or concurrent COVID-19 infection treated at 7 large hospital systems in the United States.
Observations: Males and females were equally represented in our study cohort, with a higher proportion of Black (n=8) and Hispanic (n=5) patients. All 17 patients had RT-PCR confirmed COVID-19 infection, but only 3 presented with severe COVID-19 symptoms. Acute kidney injury (AKI; n=15) and proteinuria (n=11) were the most common indications for biopsy and these symptoms developed concurrently or within 1 week of COVID-19 symptoms in all patients. Acute tubular injury (n=14), collapsing glomerulopathy (n=7) and endothelial injury/thrombotic microangiopathy (n=6) were the most common histologic findings. Two of the three transplant patients developed active antibody-mediated rejection weeks after COVID-19 infection. Eight patients required dialysis, but others improved with conservative management.
Limitations: Small study size and short clinical follow up.
Conclusions: Cases of even symptomatically mild COVID-19 infection were accompanied by AKI and/or heavy proteinuria that prompted a diagnostic kidney biopsy. While acute tubular injury was seen among the majority of them, uncommon pathology such as collapsing glomerulopathy and acute endothelial injury were detected, and most of these patients progressed to irreversible kidney injury and dialysis.
Keywords: Coronavirus disease 2019 (COVID-19); acute kidney injury (AKI); allograft biopsy; antibody-mediated rejection; case series; collapsing glomerulopathy; kidney biopsy; renal complications of COVID-19; renal pathology; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); thrombotic microangiopathy.