tetano
Editor, Senior Moderator
Am J Infect Control
. 2021 Aug 4;S0196-6553(21)00512-5.
doi: 10.1016/j.ajic.2021.07.019. Online ahead of print.
Introduction of the BNT162b2 vaccine during a COVID-19 nursing home outbreak
M Catherine McEllistrem[SUP] 1 [/SUP], Cornelius J Clancy[SUP] 2 [/SUP], Deanna J Buehrle[SUP] 3 [/SUP], Aaron Lucas[SUP] 2 [/SUP], Jennifer Pruskowski[SUP] 4 [/SUP], Steven M Handler[SUP] 4 [/SUP], Brooke K Decker[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) outbreaks often occur in nursing homes and prompt frequent surveillance testing for SARS-CoV-2. A single dose of the BNT162b2 vaccine reduces viral load and transmission. In this study, we describe the real-world efficacy of BNT162b2 single-dose vaccination during a COVID-19 outbreak at a Veterans Affairs Community Living Center (CLC).
Methods: From 12/2/20-5/14/21, twice weekly antigen testing was used to detect COVID-19 among 146 residents at the CLC. Residents without a prior history of COVID-19 who agreed to immunization were vaccinated with the BNT162b2 vaccine on 12/16/20 and 1/6/21. Single-dose vaccine efficacy was determined for days 1-21 and days 14-21 after the first vaccine dose.
Results: The outbreak occurred from 12/2/20-1/7/21 with an attack rate of 30.8% (45/146); 46.7% (21/45) of the cases were due to asymptomatic COVID-19. One unit accounted for 77.8% (35/45) of the cases. In the vaccine analysis, 116 residents were a median age of 74.5 years and 93.1% (108/116) had ≥ 1 comorbid condition. Between the first and second dose, 15.5% (15/97) of vaccinated residents, and 21.2% (4/19) of unvaccinated residents developed COVID-19 (p=0.81). One week after the second dose, no cases of COVID-19 occurred.
Conclusions: Albeit limited by the small numbers, a single dose of the BNT162b2 vaccine was not efficacious at preventing COVID-19 during this nursing home outbreak.
Keywords: Active surveillance; BNT162b2 vaccine; COVID-19; Infection Prevention; Nursing home; SARS-CoV-2; mRNA vaccine.
. 2021 Aug 4;S0196-6553(21)00512-5.
doi: 10.1016/j.ajic.2021.07.019. Online ahead of print.
Introduction of the BNT162b2 vaccine during a COVID-19 nursing home outbreak
M Catherine McEllistrem[SUP] 1 [/SUP], Cornelius J Clancy[SUP] 2 [/SUP], Deanna J Buehrle[SUP] 3 [/SUP], Aaron Lucas[SUP] 2 [/SUP], Jennifer Pruskowski[SUP] 4 [/SUP], Steven M Handler[SUP] 4 [/SUP], Brooke K Decker[SUP] 2 [/SUP]
Affiliations
- PMID: 34363871
- DOI: 10.1016/j.ajic.2021.07.019
Abstract
Background: Coronavirus disease 2019 (COVID-19) outbreaks often occur in nursing homes and prompt frequent surveillance testing for SARS-CoV-2. A single dose of the BNT162b2 vaccine reduces viral load and transmission. In this study, we describe the real-world efficacy of BNT162b2 single-dose vaccination during a COVID-19 outbreak at a Veterans Affairs Community Living Center (CLC).
Methods: From 12/2/20-5/14/21, twice weekly antigen testing was used to detect COVID-19 among 146 residents at the CLC. Residents without a prior history of COVID-19 who agreed to immunization were vaccinated with the BNT162b2 vaccine on 12/16/20 and 1/6/21. Single-dose vaccine efficacy was determined for days 1-21 and days 14-21 after the first vaccine dose.
Results: The outbreak occurred from 12/2/20-1/7/21 with an attack rate of 30.8% (45/146); 46.7% (21/45) of the cases were due to asymptomatic COVID-19. One unit accounted for 77.8% (35/45) of the cases. In the vaccine analysis, 116 residents were a median age of 74.5 years and 93.1% (108/116) had ≥ 1 comorbid condition. Between the first and second dose, 15.5% (15/97) of vaccinated residents, and 21.2% (4/19) of unvaccinated residents developed COVID-19 (p=0.81). One week after the second dose, no cases of COVID-19 occurred.
Conclusions: Albeit limited by the small numbers, a single dose of the BNT162b2 vaccine was not efficacious at preventing COVID-19 during this nursing home outbreak.
Keywords: Active surveillance; BNT162b2 vaccine; COVID-19; Infection Prevention; Nursing home; SARS-CoV-2; mRNA vaccine.