tetano
Editor, Senior Moderator
Am J Epidemiol
. 2024 Jul 3:kwae174.
doi: 10.1093/aje/kwae174. Online ahead of print. Temporal changes in the risk of six-month post-covid symptoms: a national population-based cohort study
Anne Pastorello[SUP] 1 [/SUP], Laurence Meyer[SUP] 1 2 [/SUP], Joël Coste[SUP] 3 [/SUP], Camille Davisse-Paturet[SUP] 1 [/SUP], Xavier de Lamballerie[SUP] 4 [/SUP], Maria Melchior[SUP] 5 [/SUP], Sophie Novelli[SUP] 1 [/SUP], Delphine Rahib[SUP] 3 [/SUP], Nathalie Bajos[SUP] 6 [/SUP], Cécile Vuillermoz[SUP] 1 [/SUP], Jeanna-Eve Franck[SUP] 6 [/SUP], Carmelite Manto[SUP] 1 [/SUP], Alexandra Rouquette[SUP] 1 2 [/SUP], Josiane Warszawski[SUP] 1 2 [/SUP], For The EpiCov Study Group
Affiliations
It is unclear how the risk of post-covid symptoms evolved during the pandemic, especially before the spread of Severe Acute Respiratory Syndrome Coronavirus 2 variants and the availability of vaccines. We used modified Poisson regressions to compare the risk of six-month post-covid symptoms and their associated risk factors according to the period of first acute covid: during the French first (March-May 2020) or second (September-November 2020) wave. Non-response weights and multiple imputation were used to handle missing data. Among participants aged 15 or more in a national population-based cohort, the risk of post-covid symptoms was 14.6% (95% CI: 13.9%, 15.3%) in March-May 2020, versus 7.0% (95% CI: 6.3%, 7.7%) in September-November 2020 (adjusted RR: 1.36, 95% CI: 1.20, 1.55). For both periods, the risk was higher in the presence of baseline physical condition(s), and it increased with the number of acute symptoms. During the first wave, the risk was also higher for women, in the presence of baseline mental condition(s), and it varied with educational level. In France in 2020, the risk of six-month post-covid symptoms was higher during the first than the second wave. This difference was observed before the spread of variants and the availability of vaccines.
Keywords: COVID-19; SARS-Cov-2; cohort; long covid; multiple imputation; population based; post-covid symptoms; survey weights.
. 2024 Jul 3:kwae174.
doi: 10.1093/aje/kwae174. Online ahead of print. Temporal changes in the risk of six-month post-covid symptoms: a national population-based cohort study
Anne Pastorello[SUP] 1 [/SUP], Laurence Meyer[SUP] 1 2 [/SUP], Joël Coste[SUP] 3 [/SUP], Camille Davisse-Paturet[SUP] 1 [/SUP], Xavier de Lamballerie[SUP] 4 [/SUP], Maria Melchior[SUP] 5 [/SUP], Sophie Novelli[SUP] 1 [/SUP], Delphine Rahib[SUP] 3 [/SUP], Nathalie Bajos[SUP] 6 [/SUP], Cécile Vuillermoz[SUP] 1 [/SUP], Jeanna-Eve Franck[SUP] 6 [/SUP], Carmelite Manto[SUP] 1 [/SUP], Alexandra Rouquette[SUP] 1 2 [/SUP], Josiane Warszawski[SUP] 1 2 [/SUP], For The EpiCov Study Group
Affiliations
- PMID: 38960664
- DOI: 10.1093/aje/kwae174
It is unclear how the risk of post-covid symptoms evolved during the pandemic, especially before the spread of Severe Acute Respiratory Syndrome Coronavirus 2 variants and the availability of vaccines. We used modified Poisson regressions to compare the risk of six-month post-covid symptoms and their associated risk factors according to the period of first acute covid: during the French first (March-May 2020) or second (September-November 2020) wave. Non-response weights and multiple imputation were used to handle missing data. Among participants aged 15 or more in a national population-based cohort, the risk of post-covid symptoms was 14.6% (95% CI: 13.9%, 15.3%) in March-May 2020, versus 7.0% (95% CI: 6.3%, 7.7%) in September-November 2020 (adjusted RR: 1.36, 95% CI: 1.20, 1.55). For both periods, the risk was higher in the presence of baseline physical condition(s), and it increased with the number of acute symptoms. During the first wave, the risk was also higher for women, in the presence of baseline mental condition(s), and it varied with educational level. In France in 2020, the risk of six-month post-covid symptoms was higher during the first than the second wave. This difference was observed before the spread of variants and the availability of vaccines.
Keywords: COVID-19; SARS-Cov-2; cohort; long covid; multiple imputation; population based; post-covid symptoms; survey weights.