tetano
Editor, Senior Moderator
Am J Emerg Med
. 2020 Oct 16;S0735-6757(20)30908-6.
doi: 10.1016/j.ajem.2020.10.022. Online ahead of print.
Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis
Amirhossein Hessami[SUP] 1 [/SUP], Amir Shamshirian[SUP] 2 [/SUP], Keyvan Heydari[SUP] 3 [/SUP], Fatemeh Pourali[SUP] 4 [/SUP], Reza Alizadeh-Navaei[SUP] 5 [/SUP], Mahmood Moosazadeh[SUP] 6 [/SUP], Saeed Abrotan[SUP] 7 [/SUP], Layla Shojaie[SUP] 8 [/SUP], Sogol Sedighi[SUP] 9 [/SUP], Danial Shamshirian[SUP] 10 [/SUP], Nima Rezaei[SUP] 11 [/SUP]
Affiliations
Abstract
Background: High rate of cardiovascular disease (CVD) have been reported among patients with novel coronavirus disease (COVID-19). Meanwhile there were controversies among different studies about CVD burden in COVID-19 patients. Hence, we aimed to study CVD burden among COVID-19 patients, using a systematic review and meta-analysis.
Methods: We have systematically searched databases including PubMed, Embase, Cochrane Library, Scopus, Web of Science as well as medRxiv pre-print database. Hand searched was also conducted in journal websites and Google Scholar. Meta-analyses were carried out for Odds Ratio (OR) of mortality and Intensive Care Unit (ICU) admission for different CVDs. We have also performed a descriptive meta-analysis on different CVDs.
Results: Fifty-six studies entered into meta-analysis for ICU admission and mortality outcome and 198 papers for descriptive outcomes, including 159,698 COVID-19 patients. Results of meta-analysis indicated that acute cardiac injury, (OR: 13.29, 95% CI 7.35-24.03), hypertension (OR: 2.60, 95% CI 2.11-3.19), heart Failure (OR: 6.72, 95% CI 3.34-13.52), arrhythmia (OR: 2.75, 95% CI 1.43-5.25), coronary artery disease (OR: 3.78, 95% CI 2.42-5.90), and cardiovascular disease (OR: 2.61, 95% CI 1.89-3.62) were significantly associated with mortality. Arrhythmia (OR: 7.03, 95% CI 2.79-17.69), acute cardiac injury (OR: 15.58, 95% CI 5.15-47.12), coronary heart disease (OR: 2.61, 95% CI 1.09-6.26), cardiovascular disease (OR: 3.11, 95% CI 1.59-6.09), and hypertension (OR: 1.95, 95% CI 1.41-2.68) were also significantly associated with ICU admission in COVID-19 patients.
Conclusion: Findings of this study revealed a high burden of CVDs among COVID-19 patients, which was significantly associated with mortality and ICU admission. Proper management of CVD patients with COVID-19 and monitoring COVID-19 patients for acute cardiac conditions is highly recommended to prevent mortality and critical situations.
Keywords: COVID-19; Cardiovascular disease; Meta-analysis.
. 2020 Oct 16;S0735-6757(20)30908-6.
doi: 10.1016/j.ajem.2020.10.022. Online ahead of print.
Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis
Amirhossein Hessami[SUP] 1 [/SUP], Amir Shamshirian[SUP] 2 [/SUP], Keyvan Heydari[SUP] 3 [/SUP], Fatemeh Pourali[SUP] 4 [/SUP], Reza Alizadeh-Navaei[SUP] 5 [/SUP], Mahmood Moosazadeh[SUP] 6 [/SUP], Saeed Abrotan[SUP] 7 [/SUP], Layla Shojaie[SUP] 8 [/SUP], Sogol Sedighi[SUP] 9 [/SUP], Danial Shamshirian[SUP] 10 [/SUP], Nima Rezaei[SUP] 11 [/SUP]
Affiliations
- PMID: 33268238
- DOI: 10.1016/j.ajem.2020.10.022
Abstract
Background: High rate of cardiovascular disease (CVD) have been reported among patients with novel coronavirus disease (COVID-19). Meanwhile there were controversies among different studies about CVD burden in COVID-19 patients. Hence, we aimed to study CVD burden among COVID-19 patients, using a systematic review and meta-analysis.
Methods: We have systematically searched databases including PubMed, Embase, Cochrane Library, Scopus, Web of Science as well as medRxiv pre-print database. Hand searched was also conducted in journal websites and Google Scholar. Meta-analyses were carried out for Odds Ratio (OR) of mortality and Intensive Care Unit (ICU) admission for different CVDs. We have also performed a descriptive meta-analysis on different CVDs.
Results: Fifty-six studies entered into meta-analysis for ICU admission and mortality outcome and 198 papers for descriptive outcomes, including 159,698 COVID-19 patients. Results of meta-analysis indicated that acute cardiac injury, (OR: 13.29, 95% CI 7.35-24.03), hypertension (OR: 2.60, 95% CI 2.11-3.19), heart Failure (OR: 6.72, 95% CI 3.34-13.52), arrhythmia (OR: 2.75, 95% CI 1.43-5.25), coronary artery disease (OR: 3.78, 95% CI 2.42-5.90), and cardiovascular disease (OR: 2.61, 95% CI 1.89-3.62) were significantly associated with mortality. Arrhythmia (OR: 7.03, 95% CI 2.79-17.69), acute cardiac injury (OR: 15.58, 95% CI 5.15-47.12), coronary heart disease (OR: 2.61, 95% CI 1.09-6.26), cardiovascular disease (OR: 3.11, 95% CI 1.59-6.09), and hypertension (OR: 1.95, 95% CI 1.41-2.68) were also significantly associated with ICU admission in COVID-19 patients.
Conclusion: Findings of this study revealed a high burden of CVDs among COVID-19 patients, which was significantly associated with mortality and ICU admission. Proper management of CVD patients with COVID-19 and monitoring COVID-19 patients for acute cardiac conditions is highly recommended to prevent mortality and critical situations.
Keywords: COVID-19; Cardiovascular disease; Meta-analysis.