tetano
Editor, Senior Moderator
Am J Dermatopathol
. 2023 Jun 28.
doi: 10.1097/DAD.0000000000002484. Online ahead of print. Post-Transplant Lymphoproliferative Disorder, Monomorphic Type, in a Kidney Transplant Patient After Administration of Anti-Influenza Vaccine
Angel Fernandez-Flores[SUP] 1 2 3 [/SUP], Daniel Nieto Rodriguez[SUP] 4 [/SUP], Miriam Fernandez-Parrado[SUP] 5 [/SUP], Jacques Alzoghby-Abi Chaker[SUP] 6 [/SUP], Elena Sendagorta Cudós[SUP] 4 [/SUP], Tristan Gabriel Sobral Costas[SUP] 4 [/SUP], Rafael Escudero Tornero[SUP] 4 [/SUP], Luis Miguel Valladares-Narganes[SUP] 7 [/SUP]
Affiliations
Post-transplant lymphoproliferative disorders (PTLD) are rare complications in solid organ transplant patients. Their pathogenesis is largely unknown and closely linked to low immunity, which allows uncontrolled lymphocyte proliferation. Although transplant patients receive annual influenza vaccination as a preventive protocol, we have not found any cases where the flu vaccine triggered a PTLD. We present the case of a 49-year-old female kidney transplant recipient who developed an Epstein-Barr virus-negative PTLD, CD30+ anaplastic monomorphic type, ALK-, which presented the day after a single dose of anti-influenza vaccine. The initial clinical presentation was subcutaneous, but imaging studies revealed multiorgan involvement.
. 2023 Jun 28.
doi: 10.1097/DAD.0000000000002484. Online ahead of print. Post-Transplant Lymphoproliferative Disorder, Monomorphic Type, in a Kidney Transplant Patient After Administration of Anti-Influenza Vaccine
Angel Fernandez-Flores[SUP] 1 2 3 [/SUP], Daniel Nieto Rodriguez[SUP] 4 [/SUP], Miriam Fernandez-Parrado[SUP] 5 [/SUP], Jacques Alzoghby-Abi Chaker[SUP] 6 [/SUP], Elena Sendagorta Cudós[SUP] 4 [/SUP], Tristan Gabriel Sobral Costas[SUP] 4 [/SUP], Rafael Escudero Tornero[SUP] 4 [/SUP], Luis Miguel Valladares-Narganes[SUP] 7 [/SUP]
Affiliations
- PMID: 37377227
- DOI: 10.1097/DAD.0000000000002484
Post-transplant lymphoproliferative disorders (PTLD) are rare complications in solid organ transplant patients. Their pathogenesis is largely unknown and closely linked to low immunity, which allows uncontrolled lymphocyte proliferation. Although transplant patients receive annual influenza vaccination as a preventive protocol, we have not found any cases where the flu vaccine triggered a PTLD. We present the case of a 49-year-old female kidney transplant recipient who developed an Epstein-Barr virus-negative PTLD, CD30+ anaplastic monomorphic type, ALK-, which presented the day after a single dose of anti-influenza vaccine. The initial clinical presentation was subcutaneous, but imaging studies revealed multiorgan involvement.